Impact of cytomegalovirus reactivation just before liver transplantation: A prospective cohort study

Table 1 Patient characteristics and frequency of cytomegalovirus reactivation before liver transplantation

	Total (%)	Reactivation (%)	RR (95%CI)	P value
Number of patients (%)	72 (100)	23 (32)
Gender (male)	21 (29.2)	7 (33.3)	1.09 (0.37-3.23)	0.871
Mean age, years (SD)	56.3 (9.6)	57.3 (9.2)	NA	0.900
MELD, median (IqR)	12 (14)	12 (12)	NA	0.712
Lymphocyte count, median (IqR)	929 (808)	929 (770)	NA	0.471
CMV receptor IgG-negative	5 (8.7)	2 (40)	0.68 (0.11-4.40)	0.652
HCV	46 (63.9)	15 (32.6)	1.09 (0.39-3.1)	0.872
HBV	5 (6.9)	1 (20)	0.51 (0.05-4.9)	1.000
Hepatocarcinoma	42 (58.3)	14 (33.3)	1.17 (0.42-3.2)	0.765
Fulminant hepatitis	2 (3)	0	NA	NA
Diabetes mellitus	24 (33.3)	8 (33.3)	1.1 (0.38-3.13)	0.858
Renal failure	8 (11.1)	5 (62.5)	4.26 (0.92-19.7)	0.100
Re-transplant	2 (3)	0	NA	NA

CI: Confidence interval; IqR: Interquartile range; MELD: Model for end-stage liver disease; NA: Not applicable; RR: Relative risk; SD: Standard deviation; CMV: Cytomegalovirus; HCV: Hepatitis C virus; HBV: Hepatitis B virus; IgG: Immunoglobulin G.

Table 2 Predictors of cytomegalovirus infection after liver transplantation

	CMV (%)	No CMV (%)	RR (95%CI)	P value
Number of patients (%)	16/68 (23.5)	52/68 (76.5%)
CMV reactivation before transplantation	7/16 (43.8)	15/52 (28.8)	1.91 (0.6-6.1)	0.265
Quantitative PCR pre-transplant (IU/mL), mean (SD)	2862 (5696)	868 (2756)	NA	0.154
Gender (male)	4/16 (25)	16/52 (30.8)	0.75 (0.2-2.7)	0.762
Mean age, years (SD)	55 (10.3)	57.3 (8)	NA	0.373
MELD score, median (IqR)	11 (4)	12 (11)	NA	0.254
Lymphocyte count, median (IqR)	1101 (1109)	918 (754)	NA	0.580
Organ rejection	3/16 (18.7)	8/52 (15.3)	1.27 (0.3-5.5)	0.716
CMV-negative receptor	3/16 (18.7)	1/52 (1.9)	11.7 (1.1-122.6)	0.038
Hepatitis C infection	9/16 (56.2)	34/52 (65.4)	0.7 (0.2-2.1)	0.508
Hepatitis B infection	1/16 (6.2)	4/52 (7.7)	0.8 (0.1-7.1)	0.100
Hepatocarcinoma	9/16 (56.2)	30/52 (57.7)	0.9 (0.3-2.9)	0.919
Fulminant hepatitis	0	1/52 (1.9)	NA	NA
Diabetes mellitus	6/16 (37.5)	16/52 (30.8)	1.3 (0.4-4.3)	0.615
Renal failure	2/7 (12.5)	5/52 (9.6)	1.3 (0.2-7.7)	0.664
Re-transplantation	1/16 (6.2)	1/52 (1.9)	3.4 (0.2-57.7)	0.418

CI: Confidence interval; IqR: Interquartile range; IU: International units; MELD: Model for end-stage liver disease; NA: Not applicable; RR: Relative risk; SD: Standard deviation; CMV: Cytomegalovirus.