Protein induced by vitamin K absence or antagonist II-producing gastric cancer

Table 1 Clinicopathological data of protein induced by vitamin K absence or antagonist II producing gastric cancer

Case	Age	Sex	Serum AFP (ng/mL)	Serum PIVKA-II (AU/mL)	Macroscopic type	Tumor size (cm)	Histological type	Liver metastasi	Treatment	Prognosis	Ref.
1	56	M	2810	2.45	0-IIc	6.5 × 4.5	por + tub1 + hepatoid	(-)	subtotal gastrectomy	Alive without tumor (17 mo)	[10]
2	43	M	483380	134	Borrmann 3	7.5 × 7.0	por	(+)	best supportive care	Died of disease (3 mo)	[11]
3	42	F	190	2.9	Borrmann 3	ND	por	(+)	TACE + systemic chemotherapy	Died of disease (3 mo)	[12]
4	63	M	120000	> 8	Borrmann 1	ND	por + hepatoid	(+)	systemic chemotherapy	Died of disease (2 mo)	[13]
5	72	M	14500	32.8	Borrmann 1	ND	por	(+)	best supportive care	Died of disease (1mo)	[14]
6	71	M	73	5.15	Borrmann 2	About 2	tub2	(+)	subtotal gastrectomy + enucleation of liver metastasis + HAIC	Alive (2 mo)	[15]
7	71	M	1230	28.5	Borrmann 2	About 4	por	(+)	best supportive care	Died of disease (3 mo)	[16]
8	55	M	247000	320	Borrmann 1	ND	por	(+)	systemic chemotherapy	Died of disease (4 mo)	[17]
9	71	M	18551.7	1.08	Borrmann 3	ND	tub2	(+)	systemic chemotherapy	Died of disease (5 mo)	[18]
10	87	F	490200	2.284	Borrmann 2	3.8 × 2.3/4.5 × 3.2	por + tub2 + hepatoid	(+)	best supportive care	Died of disease (1 mo)	[19]
11	49	M	21552.9	3.7	Borrmann 2	5 × 5	tub2 + hepatoid	(+)	HAIC	Died of disease (5 mo)	[20]
12	68	M	4	15.6	Borrmann 3	about 15	por + tub2	(-)	preoperative chemotherapy + pancreatico-spleno total gastrectomy	Alive without tumor (15 mo)	[21]
13	45	M	13827	0.405	Borrmann 2	ND	tub2	(+)	systemic chemotherapy	Died of disease (6 mo)	[22]
14	61	M	495.2	0.635	Borrmann 3	8.0 × 7.0/9.5 × 8.5	tub2 + pap + por + hepatoid	(+)	total gastrectomy + postoperative adjuvant chemotherapy	Died of disease (6 mo)	[23]
15	61	M	9630	0.091	Borrmann 2	4.5 × 4.0	por + hepatoid	(-)	distal gastrectomy with resection of the extra-gastric tumor	Alive without tumor (9 mo)	[24]
16	71	M	296838	56.387	Borrmann 1	ND	por + hepatoid	(+)	systemic chemotherapy	Died of disease (6 mo)	[25]

HAIC: hepatic arterial infusion chemotherapy; ND: no data; pap: papillary adenocarcinoma; por: poorly differentiated adenocarcinoma; TACE: transcatheter arterial chemoembolization; tub1: well differentiated tubular adenocarcinoma; tub2: moderately differentiated tubular adenocarcinoma; Ref: references; PIVKA-II: Protein induced by vitamin K absence or antagonist II.