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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 550-559
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.550
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.550
Intestinal microbiota: The explosive mixture at the origin of inflammatory bowel disease?
Roberto Bringiotti, Enzo Ierardi, Rosa Lovero, Giuseppe Losurdo, Alfredo Di Leo, Mariabeatrice Principi, Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy
Author contributions: Ierardi E, Di Leo A and Principi M designed the study, revised the manuscript and approved the final version; Bringiotti R, Lovero R and Losurdo G collected the data and revised the final version before approval.
Correspondence to: Enzo Ierardi, Professor, Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. ierardi.enzo@gmail.com
Telephone: +39-08-05592577 Fax: +39-08-05593088
Received: January 14, 2014
Revised: May 2, 2014
Accepted: July 27, 2014
Published online: November 15, 2014
Processing time: 308 Days and 14.8 Hours
Revised: May 2, 2014
Accepted: July 27, 2014
Published online: November 15, 2014
Processing time: 308 Days and 14.8 Hours
Core Tip
Core tip: This paper focuses on the scientific scenario regarding the potential function of gut microbiota in inflammatory bowel diseases (IBDs). Epidemiologic findings suggest that the heterogeneity and disruption of gut microbiota can be significant in modulating and addressing the immune reactions underlying IBD pathogenesis. Traditional or innovative manipulation strategies of gut microbiota may be possible future treatment options for the management of these disorders.