Copyright
©The Author(s) 2015.
World J Radiol. Nov 28, 2015; 7(11): 405-414
Published online Nov 28, 2015. doi: 10.4329/wjr.v7.i11.405
Published online Nov 28, 2015. doi: 10.4329/wjr.v7.i11.405
Table 1 Diffusion tensor imaging-derived tensor metric formulas
MD |
MD = D = (λ1 + λ2 + λ3)/3 |
FA |
FA = [(3/2) × (q/L)]1/2 = (3/2)1/2{[(λ1 - D)2+(λ2 - D)2+(λ3 - D)2]/(λ12 + λ22 + λ32)}1/2 |
RA |
RA = q/p = {[(λ1 - D)2 + (λ2 - D)2+(λ3 - D)2]1/2}/[31/2D] |
RD |
RD = (λ2 + λ3)/2 |
AD |
AD = λ1 |
Cs |
Cs = 3λ3/(λ1 + λ2 + λ3) |
p |
p = 31/2D = (λ1 + λ2 + λ3)/31/2 |
q |
q = [(λ1 - D)2 + (λ2 - D)2 + (λ3 - D)2]1/2 |
L |
L = (p2 + q2)1/2 = (λ12 + λ22 + λ32)1/2 |
Cl |
Cl = (λ1 - λ2)/(λ1 + λ2 + λ3) |
Cp |
Cp = 2(λ2 - λ3)/(λ1 + λ2 + λ3) |
Table 2 Means, SD and correlations (controlled for the effect of age and gender) in healthy brains
Tensor metric | Mean | SD | ||||||||||||
Cs | 0.756690 | 0.032259 | ||||||||||||
FA | Pearson’s R | -0.456 | FA | 0.284317 | 0.018917 | |||||||||
P-value | 0.029 | |||||||||||||
RA | Pearson’s R | -0.992 | 0.434 | RA | 0.224873 | 0.029523 | ||||||||
P-value | 0.000 | 0.039 | ||||||||||||
Cp | Pearson’s R | -0.979 | 0.460 | 0.938 | Cp | 0.133346 | 0.017086 | |||||||
P-value | 0.000 | 0.031 | 0.000 | |||||||||||
Cl | Pearson’s R | -0.946 | 0.442 | 0.978 | 0.855 | Cl | 0.111574 | 0.016583 | ||||||
P-value | 0.000 | 0.024 | 0.000 | 0.000 | ||||||||||
L | Pearson’s R | 0.372 | -0.115 | -0.416 | -0.317 | -0.186 | L | 0.002275 | 0.000100 | |||||
P-value | 0.117 | 0.578 | 0.076 | 0.200 | 0.408 | |||||||||
p | Pearson’s R | 0.179 | -0.095 | -0.214 | -0.020 | -0.014 | 0.945 | p | 0.002096 | 0.000087 | ||||
P-value | 0.477 | 0.652 | 0.395 | 0.938 | 0.953 | 0.000 | ||||||||
AD | Pearson’s R | 0.322 | -0.012 | -0.348 | -0.287 | 0.019 | 0.804 | 0.761 | AD | 0.001553 | 0.000056 | |||
P-value | 0.179 | 0.952 | 0.144 | 0.249 | 0.933 | 0.000 | 0.000 | |||||||
MD | Pearson’s R | 0.181 | -0.096 | -0.215 | -0.022 | -0.014 | 0.945 | 1.000 | 0.762 | MD | 0.001210 | 0.000050 | ||
P-value | 0.473 | 0.649 | 0.391 | 0.934 | 0.953 | 0.000 | 0.000 | 0.000 | ||||||
RD | Pearson’s R | 0.053 | -0.297 | -0.119 | 0.426 | -0.131 | 0.877 | 0.954 | 0.628 | 0.954 | RD | 0.001046 | 0.000072 | |
P-value | 0.821 | 0.132 | 0.606 | 0.054 | 0.542 | 0.000 | 0.000 | 0.001 | 0.000 | |||||
q | Pearson’s R | -0.077 | 0.698 | 0.019 | 0.257 | 0.138 | 0.138 | 0.153 | 0.393 | 0.152 | 0.406 | q | 0.000445 | 0.000055 |
P-value | 0.721 | 0.000 | 0.929 | 0.225 | 0.492 | 0.502 | 0.466 | 0.047 | 0.467 | 0.029 |
Table 3 Means, SD and correlations (controlled for the effect of age and gender) in brains with glioblastoma multiforme
Tensor metric | Mean | SD | ||||||||||||
Cs | 0.771562 | 0.066812 | ||||||||||||
FA | Pearson’s R | -0.570 | FA | 0.253531 | 0.028425 | |||||||||
P-value | 0.003 | |||||||||||||
RA | Pearson’s R | -1.000 | 0.592 | RA | 0.201778 | 0.053287 | ||||||||
P-value | 0.000 | 0.002 | ||||||||||||
Cp | Pearson’s R | -0.936 | 0.576 | 0.901 | Cp | 0.133265 | 0.043503 | |||||||
P-value | 0.000 | 0.003 | 0.000 | |||||||||||
Cl | Pearson’s R | -0.904 | 0.819 | 0.969 | 0.803 | Cl | 0.098462 | 0.011929 | ||||||
P-value | 0.000 | 0.000 | 0.000 | 0.000 | ||||||||||
L | Pearson’s R | 0.096 | 0.151 | 0.009 | -0.159 | 0.182 | L | 0.002111 | 0.000140 | |||||
P-value | 0.648 | 0.472 | 0.967 | 0.446 | 0.469 | |||||||||
p | Pearson’s R | 0.156 | -0.129 | -0.094 | -0.216 | -0.177 | 0.834 | p | 0.001961 | 0.000123 | ||||
P-value | 0.456 | 0.540 | 0.664 | 0.299 | 0.482 | 0.000 | ||||||||
AD | Pearson’s R | -0.111 | 0.343 | 0.191 | 0.053 | 0.173 | 0.871 | 0.881 | AD | 0.001397 | 0.000080 | |||
P-value | 0.596 | 0.094 | 0.372 | 0.803 | 0.492 | 0.000 | 0.000 | |||||||
MD | Pearson’s R | 0.154 | -0.125 | -0.090 | -0.215 | -0.173 | 0.837 | 1.000 | 0.883 | MD | 0.001132 | 0.000071 | ||
P-value | 0.462 | 0.550 | 0.675 | 0.303 | 0.491 | 0.000 | 0.000 | 0.000 | ||||||
RD | Pearson’s R | 0.305 | -0.411 | -0.260 | -0.360 | -0.395 | 0.706 | 0.954 | 0.699 | 0.953 | RD | 0.000999 | 0.000073 | |
P-value | 0.139 | 0.041 | 0.219 | 0.077 | 0.105 | 0.000 | 0.000 | 0.000 | 0.000 | |||||
q | Pearson’s R | -0.484 | 0.928 | 0.539 | 0.466 | 0.736 | 0.430 | 0.187 | 0.629 | 0.191 | -0.114 | q | 0.000363 | 0.000048 |
P-value | 0.014 | 0.000 | 0.007 | 0.019 | 0.001 | 0.032 | 0.371 | 0.001 | 0.361 | 0.588 |
Table 4 Estimated marginal means SE and CI of diffusion tensor imaging-derived tensor metrics (the effect of age was controlled at the value of 43.92 yr)
Tensor metric | Healthy brains | Brains with GBM | ||||||
Mean | SE | 95%CI | Mean | SE | 95%CI | |||
Lower | Upper | Lower | Upper | |||||
Cs | 0.739511 | 0.009798 | 0.719577 | 0.759446 | 0.766043 | 0.007824 | 0.750126 | 0.781960 |
FA | 0.290160 | 0.005721 | 0.278520 | 0.301799 | 0.255660 | 0.004568 | 0.246366 | 0.264954 |
RA | 0.241025 | 0.008008 | 0.224734 | 0.257317 | 0.211498 | 0.006394 | 0.198490 | 0.224506 |
Cp | 0.141366 | 0.007941 | 0.125210 | 0.157522 | 0.137961 | 0.006341 | 0.125061 | 0.150860 |
Cl | 0.119041 | 0.003243 | 0.112443 | 0.125638 | 0.099495 | 0.002589 | 0.094227 | 0.104763 |
L | 0.002287 | 0.000029 | 0.002227 | 0.002347 | 0.002103 | 0.000024 | 0.002055 | 0.002151 |
p | 0.002122 | 0.000027 | 0.002068 | 0.002177 | 0.001946 | 0.000021 | 0.001903 | 0.001990 |
AD | 0.001558 | 0.000020 | 0.001518 | 0.001598 | 0.001395 | 0.000016 | 0.001363 | 0.001426 |
MD | 0.001225 | 0.000015 | 0.001194 | 0.001257 | 0.001124 | 0.000012 | 0.001099 | 0.001149 |
RD | 0.001059 | 0.000015 | 0.001029 | 0.001089 | 0.000988 | 0.000012 | 0.000964 | 0.001012 |
q | 0.000454 | 0.000011 | 0.000432 | 0.000476 | 0.000371 | 0.000009 | 0.000354 | 0.000389 |
- Citation: Cortez-Conradis D, Rios C, Moreno-Jimenez S, Roldan-Valadez E. Partial correlation analyses of global diffusion tensor imaging-derived metrics in glioblastoma multiforme: Pilot study. World J Radiol 2015; 7(11): 405-414
- URL: https://www.wjgnet.com/1949-8470/full/v7/i11/405.htm
- DOI: https://dx.doi.org/10.4329/wjr.v7.i11.405