Catheter-based renal sympathetic nerve denervation on hypertension management outcomes

Table 1 Case reports used in this study

Ref.	Patients, n	Age (yr)	Sex	Brand
Aksu et al[21]	1	46	M	MARINER
Alegria-Barrero et al[22]	1	53	M	SYMPLICITY
Armaganijan et al[23]	1	29	F
Atas et al[24]	1	42	F	SYMPLICTY, ARDIAN
Berra et al[25]	1	54	M	SYMPLICITY
Bilge et al[26]	1,1	41, 51	F, M	.
Yap et al[27]	2	44, 69	M, M
Bonanni et al[28]	1	6	F	SYMPLICITY
Bortolotto et al[29]	1	39	F	MARINER
Celik et al[30]	1	59	M	SYMPLICITY
Chandra et al[31]	1	51	F	SYMPLICITY
Chiarito et al[32]	1	47	F	ARDIAN
Daemen et al[33]	1	55	M	RADIANCE
Ewen et al[34]	1	61	M	.
de Araújo Gonçalves et al[35]	1	67	F	SYMPLICITY
Gziut et al[36]	1	62	.	ENLIGHTN
Heradien et al[37]	1	62	F	SYMPLICITY
Himmel et al[38]	1	83	F	SYMPLICITY
Ho et al[39]	1	58	M	.
Jaguszewski et al[40]	1	72	F	ENLIGHTN
Kelle et al[41]	1	62	F	SYMPLICITY
Kiuchi et al[42]	1	15, 16, 32	F, F, M	ENLIGHTN
Koppelstaetter et al[43]	1	68	F	SYMPLICITY
Kostka-Jeziorny et al[44]	1	52	F	SYMPLICITY
Lee et al[45]	1	31	F	SYMPLICITY
Lee et al[46]	1	16	M
Luo et al[47]	1	80	F
Miller et al[48]	1	54	M
Możeńska et al[49]	1	60	M
Ott et al[50]	1	29	F	SYMPLICITY
Papademetriou et al[51]	1	59	F	ENLIGHTN
Pietilä-Effati et al[52]	4	24, 55, 56, 72	M, F, F, M	SYMPLICITY
Prejbisz et al[53]	1	26	M	SYMPLICITY
Pucci et al[54]	1	73	F	SYMPLICITY
Raju et al[55]	1	19	M	STOCKERT
Shah et al[56]	1	74	M	SYMPLICITY
Spinelli et al[57]	1	39	M	SYMPLICITY
Sridhar et al[58]	1	67	F	SYMPLICITY
Stefanadis et al[59]	1	74	M	SYMPLICITY
Tsioufis et al[60]	1	58	M
Versaci et al[61]	1	49	M	VESSIX
Wang et al[62]	1	49	M
Wu et al[63]	1	62	M	CORDIS

Table 2 Summary of arterial blood pressure measurements at different time points before and after renal sympathetic denervation

	Mean systolic blood pressure
	Prior to RSD	Time post-RSD
		24 h	1 mo	3 mo	6 mo	1 yr
All subjects	172.7 mmHg (95%CI: 165.1-180.3)	146.2 mmHg (95%CI: 131.4-161.1)	139.2 mmHg (95%CI: 124.8-153.6)	132.9 mmHg (95%CI: 114.8-151.1)	133.0 mmHg (95%CI: 120.7-145.31)	136.0 mmHg (95%CI: 118.7-153.3)
Females	170.2 mmHg (95%CI: 158.2-183.3)	147.2 mmHg (95%CI: 125.7-168.7)	137.0 mmHg (95%CI: 102.8-171.2)	136.7 mmHg (95%CI: 105.3-168.7)	130.0 mmHg (95%CI: 118.0-142.0)	134.2 mmHg (95%CI: 107.4-161.0)
Males	175.5 mmHg (95%CI: 164.7– 186.3)	144.4 mmHg (95%CI: 114.0-174.8)	137.0 mmHg (95%CI: 102.8-171.2)	126.3 mmHg (95%CI: 117.2-135.3)	1160.0 mmHg	1131.0 mmHg

¹One reported observation.

RSD: Renal sympathetic denervation.

Table 3 Comparison of quantity of antihypertensive medications used before and after renal sympathetic denervation

	Mean number of antihypertensive medications
	Pre-RSD	Post-RSD
All subjects	4.7 (95%CI: 4.1-5.4),	3.1 (95%CI: 2.3-3.9),
Females	4.9 (95%CI: 3.8-6.0)	3.0 (95%CI: 1.0–5.0)
Males	4.6 (95%CI: 3.7-5.5)	3.0 (95%CI: 1.96-4.0)

RSD: Renal sympathetic denervation.