Adaptive radiation therapy of breast cancer by repeated imaging during irradiation

Table 1 Selected studies incorporating adaptive radiation therapy for breast cancer by use of repeated imaging during the course of breast irradiation

Ref.	Year of publication	Number of patients receiving ART by use of repeated imaging	Relevant findings at initial imaging for RT	Relevant findings at repeated imaging for boost RT	P value
Oh et al[55]	2006	30	Cavity volume before WBI 32.1 cc	Cavity volume after WBI 25.1 cc	< 0.0001
Sharma et al[56]	2009	24	Median seroma volume 50 cc before WBI	Median seroma volume 29 cc at repeated CT-simulation for tumor bed boost	< 0.001
Tersteeg et al[57]	2009	77	Gross Tumor Volume before WBI 78.7 cc	Gross Tumor Volume 29.7 cc at repeated CT-simulation for tumor bed boost	< 0.001
Flannery et al[58]	2009	43	Median lumpectomy volume 38.2 cc at initial CT-simulation for WBI	Median lumpectomy volume 21.7 cc at repeated CT-simulation for tumor bed boost	< 0.001
Hurkmans et al[59]	2009	10	Boost volume 40 cc at initial CT-simulation for WBI	Boost volume 25-28 cc at repeated CT-simulations for tumor bed boost	= 0.02
Alderliesten et al[60]	2011	21	Mean seroma volume 63 cc at initial CT-simulation for WBI	Mean seroma volume 25 cc at repeated CT-simulation for tumor bed boost	< 0.001
Cho et al[61]	2011	70	Lumpectomy cavity volume 50.4 cc before WBI	Lumpectomy cavity volume 40.7 cc after WBI	< 0.001
Hurkmans et al[62]	2012	113	Tumor bed volume 70 cc at initial CT-simulation for breast RT	Tumor bed volume 45 cc at repeated CT-simulation	< 0.001
Mohiuddin et al[63]	2012	40	Median lumpectomy cavity volume 42 cc at initial CT-simulation for WBI	Median lumpectomy cavity volume 22 cc at repeated CT-simulation for tumor bed boost	< 0.001
Sager et al[45]	2018	48	Median boost target volume 33.85 cc at initial CT-simulation for WBI	Median boost target volume 14.55 cc at repeated CT-simulation for tumor bed boost	< 0.0001

ART: Adaptive radiation therapy; RT: Radiation therapy; CT: Computed tomography; WBI: Whole breast irradiation.