Revisions to the Tumor, Node, Metastasis staging of lung cancer (8th edition): Rationale, radiologic findings and clinical implications

Abstract

The Tumor, Node, Metastasis (TNM) staging system, adopted by the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), has been recently revised, with the new 8^th edition of the staging manual being published in January 2017. This edition has few but important evidence-based changes to the TNM staging system used for lung cancer. Radiologists should be aware of the updated classification system to accurately provide staging information to oncologists and oncosurgeons. In this article, we discuss the rationale, illustrate the changes with relevance to Radiology, and review the clinical implications of the 8^th edition of the UICC/AJCC TNM staging system with regards to lung cancer.

Key Words: Lung, cancer; Tumor, Node, Metastasis; Staging; 8^th edition

Core tip: This article discusses the rationale, illustrates the changes with relevance to Radiology, and reviews the clinical implications of the 8^th edition of the Union for International Cancer Control/American Joint Committee on Cancer Tumor, Node, Metastasis staging of lung cancer.

INTRODUCTION

Lung cancer is the leading oncologic cause of mortality in both men and women in the United States. Worldwide, Lung cancer, is the leading and the second most common cause of cancer death among men and women respectively[1]. The American Cancer Society estimates about 224390 new cases of lung cancer in 2016, and approximately 158000 deaths[2]. Clinical practice guidelines for lung cancer largely rely on staging models, which are used not only for predicting disease prognosis, but also to guide treatment[3]. The Tumor, Node, Metastasis (TNM) staging system, adopted by both the Union for International Cancer Control (UICC) and the American Joint Committee on Cancer (AJCC), has been recently revised, and the new edition (8^th) of the staging manual was published in January 2017[4] (Table 1). The updated lung cancer chapter introduces few but important evidence-based changes to the prior 7^th edition, derived from validation of the TNM system for staging and guiding lung cancer treatment in multidisciplinary centers.

Table 1 Lung cancer staging, Tumor, Node, Metastasis staging 8^th edition.

T	Primary tumor
	Tx	Cannot be assessed; Tumor in sputum/bronchial washings not in imaging/bronchoscopy
	To	No evidence
	Tis	Carcinoma in situ
	T1	≤ 3 cm surrounded by lung/visceral pleura, not involving main bronchus
	T1a(mi)	Minimally invasive adenocarcinoma
	T1a	≤ 1 cm
	T1b	> 1 to ≤ 2 cm
	T1c	> 2 to ≤ 3 cm
	T2	> 3 to ≤ 5 cm or Involves main bronchus without carina involvement or Visceral pleural invasion or atelectasis/post obstructive pneumonitis extending to hilum
	T2a	> 3 to ≤ 4 cm
	T2b	> 4 to ≤ 5 cm
	T3	> 5 to ≤ 7 cm or Separate tumor in same lobe or Direct invasion of chest wall (includes parietal pleura and superior sulcus)/parietal pericardium/phrenic nerve
	T4	> 7 cm or
		Separate tumor in different lobe of ipsilateral lung or Invasion of heart/ great vessels/diaphragm/mediastinum/trachea/carina/esophagus/ recurrent laryngeal nerve/vertebral body
N	Regional lymph node
	Nx	Cannot be assessed
	N0	No involvement
	N1	Ipsilateral peribronchial and/or hilar nodes and intrapulmonary nodes
	N2	Ipsilateral mediastinal and/or subcarinal nodes
	N3	Contralateral mediastinal or hilar; ipsilateral/contralateral scalene/supraclavicular
M	Distant metastasis
	M0	No distant metastasis
	M1	Distant metastasis is present
	M1a	Tumor (s) in contralateral lung; pleural/pericardial nodule/malignant effusion
	M1b	Single extrathoracic metastasis
	M1c	Multiple extrathoracic metastases, in one/more organs

In this article, we discuss the rationale, illustrate the changes with relevance to radiology and review the clinical implications of the 8^th edition of the UICC/AJCC TNM staging system.

HISTORICAL PERSPECTIVE

Developed in France by Pierre Denoix between the years 1943 and 1952, the TNM system has been adopted by the UICC and the AJCC to help clinicians plan treatment, guide prognosis, assist in treatment evaluation, provide a common language for exchange of information, and contribute to the continuing investigation of cancer[5]. Many iterations have led to the preceding 7^th UICC/AJCC TNM edition, effective since 2009, which introduced a series of evidence-based advances in comparison with earlier versions. Radiologic reviews of the 7^th TNM staging were previously published[6]. The 7^th TNM was the result of a combined effort of the International Association for the Study of Lung Cancer (IALSC), the UICC, the AJCC, and the Japanese societies against cancer[7], and reflected the conclusions from a retrospective analysis of 81015 lung cancer patients (67725 with non-small cell lung cancer, NSCLC, and 13290 with small cell lung cancer, SCLC) treated between 1990 and 2000, from Europe (59%), North America (18%), Asia (15%), and Australia (8%). The 7^th TNM edition, for the first time, encompassed small cell lung cancer (SCLC) and carcinoid tumors in the scope.

Despite these earlier efforts, some of the 7^th TNM descriptors could not be validated given the lack of a tailored methodology, leading the IALSC to commission a task force responsible for gathering and analyzing a comprehensive database, composed of both retrospective and prospective cases, in an attempt to overcome prior limitations[8]. For the first time, the database included information of 4667 patients sent via a specifically designed electronic data capture system, in addition to other sources (consortia, registries, or surgical series), resulting in a final cohort of 77156 lung cancer patients (70967 with NSCLC and 6189 with SCLC) from 35 cancer centers in 16 countries, diagnosed between 1999 and 2010 and treated with surgery or combined modalities[9]. The resultant 8^th TNM revision portrays validation of the descriptors and recommendations based on the new findings[10].

UPDATED TUMOR DESCRIPTORS (T)

The T descriptors in the 8^th TNM classification encompass size, invasion into adjacent central/mediastinal structures, and location of an additional tumor nodule in relation to the primary tumor (Table 1). The changes to the T component aim to maintain compatibility with the previous classifications, with an additional benefit of improving prognostic differentiation between the different T categories. The primary tumor is now classified into 7 categories per size (T1a, T1b, T1c, T2a, T2b, T3 and T4) as compared with the 6 categories on 7^th TNM (T1a, T1b, T2a, T2b, T3 and T4). The new T classification was validated on 33115 patients with NSCLC and no metastatic disease[9,11]. Robust analysis of the survival data was performed using a log-rank statistic, which confirmed prior 7^th TNM size cutoffs, and suggested further subdivision into 1-cm increments. T descriptors were analyzed using Cox regression analysis adjusted for age, sex, histologic type, and geographic region across multiple cohorts, with results showing a clear difference in 5-year survival, and hence prognosis, for each centimeter increase in tumor size between 1-5 cm (Table 2). The 5-cm cutoff remains useful to separate tumors with worse prognosis (T3, > 5 and ≤ 7 cm, and T4, > 7 cm).

Table 2 Five-year survival per T stage of the 8^th Tumor, Node, Metastasis staging system.

	5-yr survival
T1a	92%
T1b	83%-86%
T1c	76%-81%
T2a	67%-74%
T2b	60%-65%
T3	52%-57%
T4	38%-47%

The new classification subdivides T1 lung cancers measuring ≤ 3 cm into T1a, T1b, T1c lesions based on specific size cutoffs (Figure 1). A superficial spreading tumor in central airways is classified as T1a, regardless of its location. Carcinoma in situ is classified as Tis and applies to both adenocarcinoma and squamous cell carcinoma. Minimally invasive adenocarcinomas are classified as T1a (mi) when the invasive component is ≤ 5 mm and the noninvasive lepidic component is ≤ 3 cm (diagnoses can be only made in resected tumors).

Figure 1 Illustrations demonstrating T1 descriptors.

T2 lung cancers measure > 3 and ≤ 5 cm, and are subdivided into T2a and T2b using the 4-cm cutoff (Figure 2). Additional features in the new T2 classification include involvement of any part of the main bronchus, regardless of the distance to (but not involving) the carina. After adjusting for tumor size, partial or complete atelectasis, and pneumonitis secondary to airways invasion, these features still showed better prognosis than T3 tumors with different descriptors. Involvement of lung hilar fat is classified as T2 in 8^th TNM, as are tumors involving the visceral pleura. However, involvement of a structure by a tumor that extends from a nodal metastasis (e.g., left recurrent laryngeal nerve involved by an aortopulmonary window node metastasis) is not regarded as T involvement[10].

Figure 2 Illustrations demonstrating T2 descriptors.

For the T3 category, the new database analysis showed that tumors measuring > 5 and ≤ 7 cm, separate tumor nodules in the same lobe as the primary lesion, and invasion of structures such as the chest wall, phrenic nerve, and parietal pericardium had similar 5-year survival rate. Therefore, these criteria are described in the T3 category (Figure 3). Since the involvement of the parietal pericardium is classified as T3, invasion of the fat overlying the pericardium should be classified T3 rather than T4.

Figure 3 Illustrations demonstrating T3 descriptors.

For the T4 descriptors, tumors measuring > 7 cm in longest diameter, and tumor nodules in the same lung but different lobes as the primary lesion are included. Invasion of the diaphragm has also been upstaged to a T4 descriptor (previously T3). This is based on the 5-year survival rate, like other T4 lesions (Figure 4). Invasion of the mediastinal fat (excluding the extrapericardial fat) is classified as T4, in addition to other mediastinal structures like trachea, carina, great vessels, esophagus, recurrent laryngeal nerve, and spine, since they were associated with similar 5-year survival rate and were not changed. An important change has been to eliminate the invasion of the mediastinal pleura as a descriptor in 8^th TNM, given the inconsistency of this finding at both clinical and pathologic staging. However, involvement of the visceral pericardium is designated as T4. A superior sulcus tumor with clear involvement of the C8 or higher nerve roots or cords of the brachial plexus, subclavian vessels, and vertebral body, lamina, or spinal canal is also classified as T4, however a tumor is classified as T3 if it involves only thoracic nerve roots (e.g., a tumor involving only T1 and T2 nerve roots)[10].

Figure 4 Illustrations demonstrating T4 descriptors.

When multiple T descriptors are applicable to a tumor, the highest T category should be used to determine the category. For example, a small tumor with a higher T category by invasion should be classified by the invasion, and a large tumor with a lesser degree of invasion should be categorized by the size (e.g., a 5.3-cm tumor invading the main bronchus should be classified as T3). Some examples on how to apply the new T descriptors are shown in Figure 5.

Figure 5 T descriptors. A: T1a (mi): Groundglass opacity in the apical segment of the right upper lobe (arrow) on CT lung window image; resection revealed predominantly lepidic adenocarcinoma with 3-mm invasive component and clear margins; B: T2a: 4-cm invasive squamous cell bronchogenic carcinoma of the right upper lobar bronchus (white arrowhead) with adjacent areas of atelectasis (arrows) and clear cleavage plane with the mediastinum (yellow arrowhead) on contrast-enhanced CT image; C: T4 vs T3: 8.3cm left upper lobe mass (white arrowhead), with chest wall invasion causing destruction of the adjacent left 5th rib (arrow) and small left pleural effusion. Note that the highest descriptor should be used for T staging.

UPDATED NODE DESCRIPTORS (N)

In patients with NSCLC, lymph nodes measuring more than 1 cm in short axis on CT scans or MRI are abnormal. Reported sensitivity and specificity of CT scans for the detection of pathologic nodes is 51%-64% and 74%-86%, respectively[12]. 18-FDG PET/CT has been shown to have higher accuracy than CT or MRI, with a sensitivity of 58%-94% and specificity of 76%-96% for detection of mediastinal lymph node metastasis[13]. Contrast enhanced CT scan and 18-FDG PET/CT scans are routinely used in the clinical staging (cN) of NSCLC, whereas pathologic stage (pN) is based on histological findings.

The N staging descriptors for the 8^th TNM were validated in 70336 lung cancer patients using descriptors previously used in 6^th TNM and 7^th TNM. No changes to the N descriptors were proposed in 8^th TNM as the four N categories (N0, N1, N2, N3) based on the location of the pathologic nodes have shown to consistently predict distinct prognosis[14] (Table 3). An illustrated scheme with the current N descriptors is provided in Figure 6. Involvement of ipsilateral peribronchial and/or ipsilateral hilar nodes and intrapulmonary nodes, including direct involvement is classified as N1. Involvement of ipsilateral mediastinal nodes and/or subcarinal nodes is classified as N2. Involvement of contralateral mediastinal/hilar nodes or ipsilateral/contralateral supraclavicular/scalene nodes is classified as N3. It has been suggested that addition of the number of involved nodes in N1 and N2 locations and presence or absence of skip metastases can improve the prognostic significance of the anatomic location of involved nodes. The international association for study of lung cancer (IASLC) recommends clinical documentation of these additional parameters in 8^th TNM for further testing.

Table 3 Five-year survival per N stage of the 8^th Tumor, Node, Metastasis staging system.

	5-yr survival
N0	60%
N1	37%
N2	23%
N3	9%

Figure 6 Illustrations demonstrating N descriptors.

IASLC lymph node map provides detailed anatomic and zonal definitions for all lymph node stations[15,16]. Some examples on how to apply the new N staging descriptors are provided in Figure 7.

Figure 7 N descriptors. A: Primary tumor and N2: FDG-avid left upper lobe lung mass (arrowhead) invading the prevascular region of the mediastinum with adjacent FDG-avid level 6 lymph nodes suggesting nodal metastases (arrows); B: N1 and N2: Level 10L (white arrow), and 3A (blue arrow) enlarged lymph nodes with increased FDG avidity (N1 nodal metastases) and similar level 7 (yellow arrow) lymph nodes suggesting N2 nodal metastases; C: N3: FDG-avid left supraclavicular lymph node (arrow) suggesting N3 nodal metastases.

UPDATED METASTASIS DESCRIPTORS (M)

Metastatic disease is present in approximately 40% of patients with lung cancer at the time of initial staging with the most common sites of disease being liver, brain, bone, adrenal gland, and contralateral lung. Lung cancer metastases can occur through different routes, including hematogenous, lymphatic, airways and through air spaces. Intrapulmonary metastasis has also been used in the context of two or more malignant pulmonary lesions and no other sites of cancer. Metastatic disease may preclude surgical resection depending on the site and number of metastases. Oligometastatic disease is defined as the limited metastatic disease that may include from 1 to 5 lesions with studies showing that patients with treated oligometastases have better clinical outcomes[17].

Proposed 8^th revisions to the TNM staging system are based on significant differences in patient survival and include significant changes to the M descriptors: M0-M1 (M1 with M1a, M1b and M1c subcategories) and overall stage groupings M descriptors. An illustrated scheme of the updated M descriptors is demonstrated in Figure 8. M1a disease has not changed and comprises of intrathoracic metastases including contralateral pulmonary tumor nodules, pleural/pericardial metastatic effusion/nodules and combination of multiple of these M1a descriptors. However, extrathoracic metastatic disease has been split into M1b and M1c components based on single or multiple metastases due to significant differences in survival amongst these categories (Table 4). A single metastatic lesion involving a single distant organ is now classified as M1b category. Therefore, new M1b descriptor includes single metastatic lesion in various organs like brain, liver, bone, distant lymph node or peritoneum, skin, and adrenal. On the other hand, multiple metastases, irrespective of whether in a single distant organ or multiple distant organs, are now classified as the new M1c category. No differences in survival have been shown among different M1a descriptors or between single and multiple M1a descriptors. M1b metastatic disease is associated with survival that is similar to intrathoracic metastasis (i.e., M1a disease). Averages survival rates are 11.4 mo for M1b and 6.3 mo for M1c disease[11,17].

Table 4 Median survival per M stage of the 8^th Tumor, Node, Metastasis Staging system.

	Median survival (in months)
M1a	11.4
M1b	11.4
M1c	6.3

Figure 8 Illustrations demonstrating M descriptors.

IASLC recommends reporting the following information during staging for metastatic disease[17]: (1) identification and location of the involved site; (2) differentiation between intra- and extrathoracic metastasis; (3) number and diameter of metastatic lesions and number of involved distant organs; and (4) 18-FDG PET positivity (if available).

Reclassified M descriptors in the 8^th revision, besides maintaining the compatibility with the M descriptors of the previous 7^th edition, provide better definition of oligometastatic disease, and ability to predict prognosis, thus helping to meet the objectives of the new TNM classification[17]. Some examples of the new M descriptors are provided in Figure 9.

Figure 9 M descriptors. A: M1a: Nodular large heterogeneously enhancing right pleural mass like thickening (arrows) with mediastinal invasion (black arrowheads) and small right pleural effusion (white arrowhead) due to metastatic NSCLC; B: M1c: Two sclerotic metastases to thoracic spine (T3 and T9, arrows) from lung cancer; C: M1c: Multiple extrathoracic lung cancer metastases to the retroperitoneum (yellow arrows), right adrenal gland (white arrow), and spleen (blue arrow). Note the presence of malignant ascites (yellow arrowhead).

UPDATED STAGE GROUPS

For the validation of the staging groups in 8^th TNM, a random training set was selected from the 1999-2000 IALSC database, including 25911 and 599 cases staged M0 and M1, respectively[18]. A tree-based model algorithm for the survival data using log-rank test statistics was used for recursive partitioning and selection of the staging groups. The 8^th TNM group candidates were validated by assessing the overall survival per clinical, pathologic, and best stage. Differences in the hazard ratios between adjacent stage groups were analyzed using Cox regression analysis, adjusted for age, performance status, and cell type.

The hazard ratios between adjacent stage groups were significantly different in both 7^th TNM and 8^th TNM editions, albeit the latter introduces 4 additional levels of discrimination to the older system[18]. Thus, the new stage groups proposed by 8^th TNM could determine the 5-year survival with a higher level of detail. The goodness of fit of the survival curves (R²) were slightly better from the 7^th to the 8^th TNM editions for both pathologic (R² of 45.7 vs 46.9, respectively) and clinical stage models (R² of 67.5 vs 68.3, respectively). Tables 5 and 6 demonstrate the new stage groups of 8^th TNM and the associated 5-year survival for clinical stages respectively.

Table 5 Stage Group in the 8^th Tumor, Node, Metastasis staging system (9).

		N0	N1	N2	N3
T1/M0	T1a	IA1	IIB	IIIA	IIIB
	T1b	IA2	IIB	IIIA	IIIB
	T1c	IA3	IIB	IIIA	IIIB
T2/M0	T2a	IB	IIB	IIIA	IIIB
	T2b	IIA	IIB	IIIA	IIIB
T3/M0		IIB	IIIA	IIIB	IIIC
T4/M0		IIIA	IIIA	IIIB	IIIC
TX/M1	M1a	IVA	IVA	IVA	IVA
	M1b	IVA	IVA	IVA	IVA
	M1c	IVB	IVB	IVB	IVB

Table 6 Five-year survival per stage group of the 8^th Tumor, Node, Metastasis staging system (9).

	5-yr survival
IA1	92%
IA2	83%
IA3	77%
IB	68%
IIA	60%
IIB	53%
IIIA	36%
IIIB	26%
IIIC	13%
IVA	10%
IVB	0%

CHALLENGES OF THE NEW STAGING SYSTEM

There are a few challenges related to the latest TNM staging system for lung cancer.

Small-cell lung cancer and carcinoid tumors

A single system has been proposed to stage NSCLC, small-cell lung cancer (SCLC), and bronchial carcinoids since the 7^th TNM edition[4]. The 1999-2010 IALSC database was used for validating the TNM system in 5002 cases of SCLC. Interestingly, carcinoid tumors were excluded from the analysis; therefore, validation for this histologic subtype is still lacking despite the current recommendations[9].

Although prognostic information by T and N descriptors matched between SCLC and NSCL, some peculiarities arose when analyzing the M descriptors. M1b patients with SCLC and single-site brain metastasis had better prognoses than those with single-site metastasis elsewhere. Likewise, the presence of pleural effusion in patients with M1b disease conferred an independent worse prognosis[19].

Assessing multifocal pulmonary cancer

Specific guidelines have been published for addressing cases with involvement of more than one pulmonary site[20]. IASLC recommends that patients with multiple lung lesions be assessed in a multidisciplinary tumor board. The most important question to be answered is the histology of the separate lesions. For different histologic subtypes, a second primary cancer is favored and separate T, N, and M should be provided for each tumor. If the same histologic subtype is found, a single staging should be provided, with T3 descriptor used for lesions in the same lobe, T4 for ipsilateral lesions in different lobes, and M1a for contralateral lesions.

In patients with multiple groundglass lesions (lepidic tumors), the T descriptor is determined by the size and characteristics of the dominant abnormality. In this setting, the T descriptor can be listed with the total number of lesions indicated in parentheses[20]. For example, a patient with three groundglass nodules, the largest measuring 1.4 cm, would be staged as cT1b(3), regardless of the location of the nodules (i.e., same or different lobes). The N/M staging in this context refers to the whole set of lesions[20].

Diffuse pneumonic-type lung cancer is categorized as T3 if in one lobe, T4 if involving multiple same-side lobes, and M1a if involving both lungs with a single N and M category for all areas of involvement.

Assessing tumor size

Specifications on how to measure the lesion size are clearly addressed in the data, although there is no clear mention about the imaging procedures that should be used to achieve this goal[21,22]. In addition, some lesions with necrosis/cavitation, ill-defined margins, and post obstructive pneumonitis or radiation changes may create a challenge to the most experienced reader[22]. Figure 10 illustrates one challenging case for radiologists. Multiple parameters like slice-thickness, reconstruction settings, degree of inspiration, and other scanner parameters are known to affect the observed size, with significant inter and intra-observer variability for size measurements in smaller lesions[23]. Automatic and semiautomatic 3D tools for assessing lesion size are more available, resulting in less variability[24], and may guide future improvements in the TNM system.

Figure 10 Challenging cases. A: A 65-year-old man with a non-calcified spiculated lesion in the left upper lobe in the region of confluent pulmonary emphysema. The lesion reveals markedly irregular shape, with the solid component measuring 2.5 cm on computed tomography (CT) (arrow), which would put the lesion in the cT1c category. A separate solid nodule in the same lobe (arrowhead) would upstage the tumor to cT3; B: CT images at the cervicothoracic junction revealed large left thyroid lobe mass (arrow). The analysis of the left lung upper lobectomy specimen revealed a 3.2 cm primary lung adenocarcinoma, with the second nodule in the thyroid representing a metastatic thyroid cancer (pT2a lung cancer).

For subsolid lesions, the maximum dimension of the solid component on imaging or the invasive component on microscopy is used to assign the T category[21]. However, it is recommended that the maximum dimension of the groundglass or lepidic component be also noted.

Lymphangitis carcinomatosa

The pathologic changes seen in lymphangitis carcinomatosa are characterized by the infiltration of pulmonary lymphatics by malignant cells, usually presenting with symptoms of hypoxemia, with poor prognosis[25] The classic appearance on CT is thickening (smooth, irregular, or nodular) of the peribronchovascular and interlobular interstitium[26]. Despite its potential prognostic information, lymphangitis carcinomatosa has not been added as a descriptor in neither the 7^th nor the 8^th TNM editions[10,22].

Assessing number of nodes and other nodal chains

Although the N classification has not changed since the prior 7^th edition, a significant limitation of the new IASLC lung cancer database must be mentioned. The anatomical location of lymph node involvement in the new database was defined by either the Naruke (for Japanese data) or Mountain-Dresler modification of the American Thoracic Society MDATS (for non-Japanese data) nodal charts, which are discrepant in the definition of subcarinal nodes. Naruke map considers subcarinal lymph nodes along the inferior border of the main stem bronchus to be station 10 (N1), whereas MDATS map considers them station 7 (N2) nodes. Further validation of the unified nodal chart sponsored by IALSC[15] must be pursued in the future.

In addition to the site analysis, another analysis was performed to determine the prognostic impact of adding the number of involved lymph node stations and presence of skip metastases to the present nodal categories. According to the number of involved lymph node stations (single vs multiple), pN categories were further subdivided: N1 was divided into N1-single (N1a) and N1-multiple (N1b) and N2 was divided into N2-single (N2a) and N2-multiple (N2b). N2a was further subdivided into single skip-metastatic N2 node without N1 involvement (N2a1) and single N2 node with N1 involvement (N2a2). Patients with pN2 metastasis at a single lymph node station without hilar involvement (skip metastasis) had better survival than those with pN1 metastasis at multiple stations. The number of involved nodal stations was found to have prognostic impact on pathologic staging, but was not validated in clinical staging.

There is lack of consensus in how to treat less common nodal sites of metastasis, such as internal thoracic, cardiophrenic, axillary, subpectoral, and extrathoracic chains. Some authors suggest that all chains not included in the N descriptors be considered as M1 disease[16,17], whereas others consider N3 disease for specific sites (e.g., axillary chains)[27]. Further clarification is thus necessary.

FUTURE DIRECTIONS

Metastatic disease

Although the new M descriptors evolved to distinguish single-site vs multiple-site metastasis, no detailed distinction is made based on the specific site or metastatic burden[10]. However, IASLC made recommendation for recording ancillary information that may provide basis for future development, including the number of metastatic lesions, diameter of individual metastatic lesions, and number of involved organs. Moreover, recording the histologic confirmation and/or standard uptake values from 18-FDG PET/CT of metastatic sites is also suggested for future analysis[17].

Imaging standardization

Specific efforts to standardize imaging acquisition and interpretation protocols are necessary for improving efficacy, reproducibility, and communication of radiologic results. Pathways mapped by other radiology-led programs, such as lung cancer screening[28], may provide future directions in lung cancer staging to be followed by radiologic societies.

CONCLUSION

The 8^th edition of the TNM system for lung cancer staging consolidates and expands the base of evidence currently used for predicting prognosis and guiding patient treatment. As new stage groups are shown to demonstrate better precision for determining prognosis, it is expected that improvements in tailoring patient treatment will follow with adoption of the new staging system. It is of utmost importance that radiologists familiarize with the new system to provide accurate communication with referring physicians. Further collection of prospective data and detailed attention to unanswered questions will guide developments for future staging systems.

ACKNOWLEDGMENTS

The authors would like to acknowledge the contribution of Erin Moore, MA with illustrations for this manuscript.