Two-point Dixon and six-point Dixon magnetic resonance techniques in the detection, quantification and grading of hepatic steatosis

Figure 1 Bland Altman plots demonstrate the inter-test variability for fat fraction estimates. A: Two-point Dixon vs magnetic resonance spectroscopy (MRS); B: Six-point Dixon vs MRS; C and D: Patients with and without liver iron overload on six-point Dixon vs MRS. MRS: Magnetic resonance spectroscopy.

Figure 2 Bland Altman plots demonstrate the inter-test variability for fat fraction estimates vs magnetic resonance spectroscopy for patients with and without liver fibrosis on two-point Dixon and six-point Dixon. A: Two-point Dixon vs magnetic resonance spectroscopy (MRS) in patients with liver fibrosis; B: Six-point Dixon vs MRS in patients with liver fibrosis; C: Two-point Dixon vs MRS in patients without liver fibrosis; D: Six-point Dixon vs MRS in patients without liver fibrosis. MRS: Magnetic resonance spectroscopy.

Figure 3 Scatterplots demonstrate a strong linear relationship. A: Scatterplots demonstrate a strong linear relationship between two-point Dixon vs magnetic resonance spectroscopy (MRS); B: Scatterplots demonstrate a strong linear relationship between six-point Dixon vs MRS for liver fat quantification. MRS: Magnetic resonance spectroscopy; PDFF: Proton density fat fraction.

Figure 4 Receiver operating characteristic analysis demonstrates excellent accuracy for detecting hepatic steatosis on two-point Dixon and six-point Dixon. A: Two-point Dixon; B: Six-point Dixon. AUC: Area under the curve.

Figure 5 Receiver operating characteristic analysis. A: The accuracy for grading mild hepatic steatosis on two-point Dixon and six-point Dixon; B: The accuracy for grading moderate hepatic steatosis on two-point Dixon and six-point Dixon; C: The accuracy for grading severe hepatic steatosis on two-point Dixon and six-point Dixon. Two-point Dixon was performed in patients with no iron overload while six-point Dixon was performed in a mixed cohort of patients with and without iron overload. AUC: Area under the curve.

Figure 6 Receiver operating characteristic analysis. A: Receiver operating characteristic (ROC) analysis demonstrates excellent accuracy for grading mild hepatic steatosis on six-point Dixon in patients with no iron overload; B: ROC analysis demonstrates good accuracy for detecting hepatic steatosis on ultrasound. AUC: Area under the curve.

Figure 7 Receiver operating characteristic analysis shows the accuracy for grading mild, moderate and severe hepatic steatosis on ultrasound. A: The accuracy for grading mild hepatic steatosis on ultrasound; B: The accuracy for grading moderate hepatic steatosis on ultrasound; C: The accuracy for grading severe hepatic steatosis on ultrasound. AUC: Area under the curve.