Impairment of aspirin antiplatelet effects by non-opioid analgesic medication

doi:10.4330/wjc.v7.i7.383

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Jul 26, 2015 (publication date) through Jul 29, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Jul 26, 2015; 7(7): 383-391
Published online Jul 26, 2015. doi: 10.4330/wjc.v7.i7.383

Table 1 Risk and benefits of non-opioid analgesics

Substance	Plateletinhibition	Aspirin interaction	Benefits	Risks
Aspirin	Irreversible	-	Analgesic, antipyretic, anti-inflammatory	Bleeding events
Aspirin	Irreversible	-	Reduction of cardiovascular events and death	Bleeding events
Ibuprofen	Reversible (half-life 1-4 h)	Yes	Analgesic, antipyretic, anti-inflammatory	Death
				Cardiovascular events
				Bleeding events
Naproxen	Reversible (half-life 12-24 h)	Yes	Analgesic, antipyretic, anti-inflammatory	Bleeding events
Naproxen	Reversible (half-life 12-24 h)	Yes	Reduction of cardiovascular events (?)	Bleeding events
Diclofenac	Reversible (half-life 1-2 h)	No	Analgesic, antipyretic, anti-inflammatory	Death
				Cardiovascular events
				Bleeding events
Celecoxib	Reversible (half-life 8-13 h)	Yes	Analgesic, antipyretic, anti-inflammatory	Death
Celecoxib	Reversible (half-life 8-13 h)	Yes	Less gastrointestinal events	Cardiovascular events
Paracetamol	Reversible (half-life 1-4 h)	No	Analgesic, antipyretic	Cardiovascular events
Paracetamol	Reversible (half-life 1-4 h)	No	Less gastrointestinal events	Cardiovascular events
Dipyrone	Reversible (half-life 2-4 h)	Yes	Analgesic, antipyretic, anti-inflammatory	Risk of death and cardiovascular events not investigated
Dipyrone	Reversible (half-life 2-4 h)	Yes	Less gastrointestinal events	Risk of death and cardiovascular events not investigated

Citation: Polzin A, Hohlfeld T, Kelm M, Zeus T. Impairment of aspirin antiplatelet effects by non-opioid analgesic medication. World J Cardiol 2015; 7(7): 383-391
URL: https://www.wjgnet.com/1949-8462/full/v7/i7/383.htm
DOI: https://dx.doi.org/10.4330/wjc.v7.i7.383