Assessment of coronary artery disease using coronary computed tomography angiography and biochemical markers

Table 1 Table summarizing the current key studies on comprehensive “bio-imaging” with coronary computed tomography and biomarkers in presumably stable coronary artery disease patients

Ref.	Biochemical markers	CT scanner	Number of patients	Results
Laufer et al[59]	hsTnT	64-sl. MDCT	615	Even mild CAD is associated with hsTnT levels in symptomatic patients
Korosoglou et al[58]	hsTnT	≥ 64-sl. MDCT	124	hsTnT is associated with the extend of positive remodeled NCP. Only weak association was detected for hsCRP
Blaha et al[68]	hsCRP	4-sl. MDCT	6762	hsCRP was not associated with coronary artery calcification
Duivenvoorden et al[70]	hsCRP, MPO, and others	18FDG-PET/CT	130	MPO levels are associated with carotid plaque inflammation
Andrassy et al[62]	HMBG-1	256-sl. MDCT	152	HMBG1 is associated with the composition and extend of atherosclerotic plaques
Nakazato et al[64]	LDL, HDL, TC	≥ 64-sl. MDCT	4575	Presence and extend of NCP are associated with high non-HDL level
Voros et al[63]	ApoB, HDL, LDL	64-sl. MDCT IVUS/VH	60	ApoB and small HDL particles are associated with larger plaque burden and more NCP plaque. Larger HDL and pre-b2-HDL particles are associated with plaque burden and less NCP

CAD: Coronary artery disease; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; ApoB: Apolipoprotein B; TC: Total cholesterol; hsTnT: High-sensitive Troponin T; hsCRP: High-sensitive C-reactive protein; MPO: Myeloperoxidase; MDCT: Multi-slice computer tomography.