Effect of genetic factors on the association between coronary artery disease and PTPN22 polymorphism

Table 1 Proportion of *T allele of PTPN22 in relation to the presence of *A allele of acid phosphatse locus 1 polymorphism

	Proportion of carriers of *T allele of PTPN22		Total of subjects, n
Non diabetic subjects with CAD
Subjects carrying the *A allele	19.3%		62
Other ACP1 genotypes	7.0%		71
Non diabetic subjects with cardiovascular diseases without CAD
Subjects carrying the *A allele	3.4%		59
Other ACP1 genotypes	6.3%		63
Blood donors
Subjects carrying the *A allele	7.2%		138
Other ACP1 genotypes	4.6%		131
Statistical analysis		χ2 test of independence
	χ2	df	P
Carriers of *A allele	10.598	2	0.005
Other ACP1 genotypes	0.998	2	0.742

CAD: Coronary artery disease; ACP₁: Acid phosphatse locus 1.

Table 2 Proportion of carriers of *T allele of PTPN22 in relation to the presence of the *Pro allele of p53 codon 72 polymorphism

	Proportion of carriers of *T allele of PTPN22		Total of subjects, n
Non diabetic subjects with CAD
*Arg/*Arg genotype	7.6%		66
Carriers of *Pro allele	17.5%		63
Non diabetic subjects with cardiovascular diseases without CAD
*Arg/*Arg genotype	9.2%		65
Carriers of *Pro allele	0.0%		52
Blood donors
*Arg/*Arg genotype	7.2%		139
Carriers of *Pro allele	5.1%		117
Statistical analysis		χ2 test of independence
	χ2	df	P
*Arg/*Arg genotype	1.212	2	0.545
Carriers of *Pro allele	11.248	2	0.004

CAD: Coronary artery disease. Adapted from reference [13].

Table 3 Proportion of carriers of *T allele of PTPN22 in relation to the presence of the adenosine deaminase locus 2 *2 allele of adenosine deaminase locus 2 polymorphism

	Proportion of carriers of *T allele of PTPN22		Total of subjects, n
Non diabetic subjects with CAD
ADA2 *1/*1 genotype	8.3%		84
Carriers of ADA2 *2 allele	20.8%		48
Non diabetic subjects with cardiovascular diseases without CAD
ADA2 *1/*1 genotype	6.7%		75
Carriers of ADA2 *2 allele	2.2%		46
Blood donors
ADA2 *1/*1 genotype	4.5%		88
Carriers of ADA2 *2 allele	5.1%		59
Statistical analysis		χ2 test of independence
	χ2	df	P
ADA2 *1/*1 genotype	1.024	2	0.599
Carriers of ADA2 *2 allele	11.747	2	0.003

CAD: Coronary artery disease; ADA₂: Adenosine deaminase locus 2.