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Copyright ©2014 Baishideng Publishing Group Inc.
World J Cardiol. May 26, 2014; 6(5): 277-282
Published online May 26, 2014. doi: 10.4330/wjc.v6.i5.277
Table 1 Study and patients characteristics
Ref.Study group
Period (wk)Study arm
EndpointResults (mean)
Disease, therapy, patientsNumber (I/C)InterventionControlIntervention(mmHg)Control(mmHg)Difference intervention vs control (mmHg)
Schein et al[9], 2001; IsraelHT, medication, BP ≥ 140/90, 25-75 yr32/338Resperate® 10 min/dWalkman 10 min/dSBP DBP156.6 > 141.4154.7 > 143.4-2.9 (-2.8-10.6)
96.7 > 86.7a93.4 > 87.8-4.4a (1.1-7.6)
Grossman et al[10], 2001; IsraelHT, medication, BP ≥ 140/90, 25-75 yr18/158Resperate® 10 min/dWalkman 10 min/dClinic, SBP DBP Home, SBP DBP160 > 152.5 95 > 91 157 > 152.0 94 > 91.3155 > 152.1 94 > 92.5 151 > 149.8 90 > 90.9-4.6a -2.5 -3.8 -3.6a
Rosenthal et al[11], 2001; IsraelHT, medication, BP 130/85-180/110, 25-75 yr13/-8Resperate® 15 min/d-24 h, SBP DBP137.1 > 129.9a 82.5 > 80.2- -- -
Viskoper et al[12], 2003; IsraelHT, medication, SBP 140-160 or DBP 90-100, 40-80 yr17/-8Resperate® 15 min/d-Home, SBP DBP Clinic, SBP DBP156.4 > 150.0a 88.5 > 85.9a 155.4 > 142.5a 88.9 > 82.0a- - - -- - - -
Meles et al[13], 2004; ItalyHT, 40-75 yr + 1) not treated, SBP 140-159 or DBP 90-99; OR = 2) medication and BP > 140/9048/318Resperate® 15 min/dBP 1/dHome, SBP DBP Clinic, SBP DBP137 > 131.6a 83 > 79.8a 141.4 > 135.9 88.1 > 84.5a126 > 124.1 79 > 78.0 133.2 > 133.0 85.9 > 86.8-3.5a -2.2a -5.3 -4.5a
Elliot et al[14], 2004; United StatesHT, medication, SBP 140-179, DBP < 110, 40-75 yr89/608Resperate® 15 min/dBP 3/dClinic, SBP DBP Home, SBP DBP150.3 > 139.7 84.7 > 81.5 145.8 > 145.3 85.9 > 85.3149.8 > 140.6 86.8 > 83.6 141.3 > 141.9 83.7 > 83.5-1.4 0.0 -1.1 -0.4
Logtenberg et al[15], 2007; The NetherlandsT2DM, HT, medication, SBP 140-160, > 18 yr15/158Resperate® 15 min/dDiscman 15 min/dClinic, SBP DBP Home, SBP DBP153.5 > 146.0 83.0 > 82.0 - -150.4 > 138.2 87.0 > 81.5 - -4.7 (-11.7-2.3) 4.6 (-10.4-2.3) 1.0 (-7.8-5.8) 1.3 (-5.8-3.2)
Altena et al[16], 2008; The NetherlandsHT, medication SBP 140-160, > 18 yr15/158Resperate® 15 min/dDiscman 15 min/dClinic, SBP DBP Home, SBP DBP-9.8 -4.6 -2.5 -4.9-5.6 -2,0 -2.9 -3.4-4.2 (-12.4-3.9) -2.6 (-8.4-3.3) 0.5 (-3.7-4.8) -1.8 (-8.4-4.8)
Schein et al[17], 2009; IsraelT2DM, HT, medication, SBP >13033/338Resperate® 15 min/dUsual careClinic, SBP DBP150 > 140 81 > 77147 > 149 81 > 80-12a -3
Anderson et al[18], 2010; United StatesStage 1 HT or pre-hypertension, no medication, no CVD or T2DM.20/204Resperate® 15 min/dMeditative exercise 15 min/dClinic, SBP DBP 24h, SBP DBP141.8 > ? 88.2 > ? 138.2 > 137.7 84.6 > 83.8140.1 > ? 85.2 > ? 137.3 > 137.8 80.4 > 81.8- - -1 -2.2
Bertisch et al[19], 2011; United StatesHT and OSA, medication or untreated, BP 120/80-160/100, 20-75 yr25/-8BiPAP® 15 min/d-Clinic, SBP DBP140 > 130.4a 82.7 > 80.2- -- -
Landman et al[20], 2013; The NetherlandsT2DM, HT, medication, SBP 140-160, ≥ 18 yr24/248Resperate® 15 min/dSham- Device 15 min/dClinic, SBP DBP Home, SBP DBP151.6 > 145.6 82.1 > 76.2 ? ?151.2 > 142.8 80.7 > 77.0 ? ?2.4 (-6.5-11.2) -2.3 (-6.7-2.2) -3.0 (-13.2-7.2) 0.1 (-6.9-7.1)
Howorka et al[21], 2013; AustriaT2DM, HT, medication, BP < target value, 18-78 yr16/168Resperate® 12 min/dUsual care24h, SBP DBP Daytime SBP DBP126.1 > 123.2a ? 129.3 > 127.1 ?? ? ? ?? (P = 0.18) ? (P = 0.43)
Table 2 Randomized controlled trials with an active control group: methodological quality
CriteriaSchein[9]Grossman[10]Logtenberg[15]Altena[16]Anderson[18]Landman[20]
Randomization adequate+/-+++-+
Treatment allocation concealed+?++-+
Groups similar at baseline++++++
Patient blinded+/-+/-++-+
Care provider blinded+/-+/----+
Outcome assessor blinded-?---+
Co-interventions avoided++/-?+?+
Compliance acceptable+?++++
Withdrawal/drop-out rate acceptable++++++
Timing of outcome assessment similar++++++
Intention to treat analyses+/-+++-+