Patients with cardiac disease: Changes observed through last decade in out-patient clinics

Table 1 Comparative characteristics of the patients included in each registry

	1999	2009	P vaule
Number	6194	4639
Age (yr)	66.7 ± 10.8	70.6 ± 11.3	< 0.01
Age >70 yr	45.1% (44.7-45.5)	56.9% (56.0-57.8)	< 0.01
Age > 80 yr	13.0% (12.9-13.1)	18.6% (18.5-18.7)	< 0.01
Males	54% (53.4-54.6)	57.2% (56.3-58.1)	< 0.01
BMI > 30 mg/m2	30% (29.8-30.2)	31.9% (31.6-32.2)	0.02
Hypertension	65% (64.1-65.9)	85.8% (83.8-87.8)	< 0.01
Diabetes	21% (20.9-21.1)	38.2% (37.8-38.6)	< 0.01
Dyslipidemia	40% (39.7-40.3)	59.2% (58.2-60.2)	< 0.01
Current smokers	20% (19.9-20.1)	12.1% (12.0-12.2)	< 0.01
Left ventricle hypertrophy	24.0% (23.9-24.1)	30.9% (30.6-31.2)	< 0.01
Systolic BP (mmHg)	138.2 ± 15.2	136.6 ± 16.0	< 0.01
Diastolic BP (mmHg)	79.1 ± 10.9	78.6 ± 11.5	< 0.01
BP < 140/90 mmHg	36.0% (35.7-36.3)	55.6% (54.8-56.4)	< 0.01

Data collected from CARDIOTENS registries, Spain. Data are presented as mean ± SD or percentage (99%CI). BMI: Body mass index; BP: Blood pressure.

Table 2 Lipid profile of patients included in each registry

	1999	2009	P vaule
Total cholesterol (mg/dL)	218.3	196.3 (45.8)	< 0.01
HDL (mg/dL)	49.5	50.2 (15.3)	< 0.01
LDL (mg/dL)	145.1	117.0 (37.5)	< 0.01
Triglycerides (mg/dL)	142.6	145.1 (70.5)	0.02

Data collected from CARDIOTENS registries, Spain. HDL: High-density lipoproteins; LDL: low-density lipoproteins.

Table 3 Medical treatments in each registry

	1999	2009	P vaule
Antiplatelets	42.0% (41.6-42.4)	76.8% (75.2-78.4)	< 0.01
Diuretics	32.0% (31.8-32.2)	4.4% (4.39-4.41)	< 0.01
ACEI	30.2% (30.0-30.4)	43.6% (43.1-44.1)	< 0.01
Statins	27.0% (26.9-27.1)	65.1% (63.9-66.3)	< 0.01
CCB	27.8% (27.6-28.0)	36.7% (36.3-37.1)	< 0.01
Nitrates	25.0% (24.9-25.1)	26.3% (26.1-26.5)	0.06
Beta-blockers	22.2% (22.1-22.3)	44.6% (44.1-45.1)	< 0.01
Oral anticoagulants	17.5% (17.4-17.6)	27.0% (26.8-27.2)	< 0.01
ARB	11.1% (11.0-11.1)	38.6% (38.2-39.0)	< 0.01
Insulin	5.1% (5.09-5.10)	13.7% (13.6-13.8)	< 0.01
Oral antidiabetics	10.0% (9.9-10.1)	43.7% (43.2-44.2)	< 0.01

Data collected from CARDIOTENS registries, Spain. Data presented as percentages (99%CI). ACEI: Angiotensin converter-enzyme inhibitors; ARB: Angiotensin receptor blockers; CCB: Calcium channel blockers.