Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension

doi:10.4330/wjc.v5.i5.132

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May 26, 2013 (publication date) through Feb 21, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. May 26, 2013; 5(5): 132-140
Published online May 26, 2013. doi: 10.4330/wjc.v5.i5.132

Table 1 Antropometric, clinical and biochemical characteristics of study participants (mean ± SD) n (%)

Characteristics
Age, yr	65.1 ± 9.8
BMI, kg/m²	26.2 ± 4.7
SBP, mm/Hg	138 ± 19
DBP, mm/Hg	83 ± 9
Cholesterol, mg/dL	234 ± 49
TG, mg/dL	125 ± 70
HDL cholesterol, mg/dL	66 ± 11
LDL cholesterol, mg/dL	143 ± 47
EH	120 (61)
LVH	53 (27)
CHD	45 (23)
Type 2 diabetes	23 (12)
Myocardial infarction	8 (4)
Family history of EH	75 (38)
Family history of myocardial infarction	51 (26)

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; EH: Essential hypertension; LVH: Left ventricular hypertrophy; CHD: Coronary heart disease; TG: Triglycerides; HDL: High density lipoproteins; LDL: Low density lipoproteins.

Table 2 Antropometric, clinical and biochemical characteristics of study participants from the 1^st and 2^nd quartiles of distribution of 15059G>A heteroplasmy level n (%)

Characteristics	15059G>A heteroplasmy level¹		P value
Characteristics	Quartile 1 (n = 49)	Quartile 4 (n = 48)
Age, yr	60.1 ± 7.1	66.2 ± 9.9	0.001
BMI, kg/m²	26.4 ± 4.5	27.1 ± 5.1	0.41
SBP, mm/Hg	132 ± 18	143 ± 22	0.022
DBP, mm/Hg	83 ± 12	84 ± 12	0.50
Cholesterol, mg/dL	228 ± 42	243 ± 43	0.10
TG, mg/dL	112 ± 57	141 ± 61	0.021
HDL cholesterol, mg/dL	66 ± 14	68 ± 19	0.69
LDL cholesterol, mg/dL	140 ± 40	147 ± 44	0.44
EH	22 (45)	30 (63)	0.17
LVH	13 (27)	13 (27)	0.97

¹Data are mean ± SD. BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; EH: Essential hypertension; LVH: Left ventricular hypertrophy; TG: Triglycerides; HDL: High density lipoproteins; LDL: Low density lipoproteins.

Table 3 Antropometric, clinical and biochemical characteristics of coronary heart disease patients from the 1^st and 2^nd quartiles of distribution of 15059G>A heteroplasmy level n (%)

Characteristics	15059G>A heteroplasmy level¹		P value
Characteristics	Quartile 1 (n = 11)	Quartile 4 (n = 10)
Age, yr	63.2 ± 7.0	72.9 ± 8.7	P value	0.011
BMI, kg/m²	27.2 ± 6.2	26.1 ± 5.9	0.69
SBP, mmHg	129 ± 22	153 ± 22	0.03
DBP, mmHg	80 ± 12	85 ± 13	0.32
Cholesterol, mg/dL	224 ± 54	236 ± 49	0.59
TG, mg/dL	130 ± 77	121 ± 56	0.78
HDL cholesterol, mg/dL	62 ± 15	69 ± 15	0.39
LDL cholesterol, mg/dL	136 ± 47	143 ± 42	0.69
EH	7 (64)	7 (70)	0.86
LVH	4 (36)	4 (40)	0.68

Table 4 Antropometric, clinical and biochemical characteristics of CHD-free study participants from the 1^st and 2^nd quartiles of distribution of 15059G>A heteroplasmy level n (%)

Characteristics	15059G>A heteroplasmy level¹		P value
Characteristics	Quartile 1 (n = 38)	Quartile 4 (n = 37)
Age, yr	59.4 ± 7.2	64.7 ± 8.8	P value	0.005
BMI, kg/m²	26.0 ± 4.0	27.4 ± 5.3	0.2
SBP, mmHg	132 ± 14	141 ± 21	0.17
DBP, mmHg	84 ± 11	84 ± 10	0.99
Cholesterol, mg/dL	231 ± 41	246 ± 47	0.14
TG, mg/dL	106 ± 46	147 ± 61	0.003
HDL cholesterol, mg/dL	67 ± 14	67 ± 18	0.99
LDL cholesterol, mg/dL	143 ± 37	150 ± 42	0.44
EH	15 (39)	23 (62)	0.19
LVH	10 (26)	10 (27)	0.98

Table 5 Comparison of antropometric, clinical and biochemical characteristics of study participants from “low heteroplasmy” and “high heteroplasmy” groups n (%)

Characteristics	15059G>A heteroplasmy level¹		P value
Characteristics	Low (n = 99)	High (n = 97)
Age, yr	60.2 ± 8.4	68.6 ± 8.4	P value	< 0.001
BMI, kg/m²	26.3 ± 4.1	27.0 ± 5.0	0.52
SBP, mmHg	133 ± 16	142 ± 18	0.024
DBP, mmHg	82 ± 11	84 ± 11	0.39
Cholesterol, mg/dL	232 ± 48	241 ± 48	0.27
TG, mg/dL	118 ± 56	135 ± 62	0.065
HDL cholesterol, mg/dL	67 ± 14	66 ± 15	0.92
LDL cholesterol, mg/dL	141 ± 42	148 ± 44	0.49
EH	51 (52)	69 (71)	0.033
LVH	20 (20)	33 (34)	0.1

Table 6 Association between the 15059G>A heteroplasmy level and essential hypertension prevalence

15059G>A heteroplasmy level	No hypertension, n	Hypertension, n	Odds ratio (95%CI)	P value
Low (< 31%)	51	51
High (> 31%)	25	69	2.76 (1.45-5.27)	0.019
Total	76	120

Citation: Sobenin IA, Chistiakov DA, Sazonova MA, Ivanova MM, Bobryshev YV, Orekhov AN, Postnov AY. Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension. World J Cardiol 2013; 5(5): 132-140
URL: https://www.wjgnet.com/1949-8462/full/v5/i5/132.htm
DOI: https://dx.doi.org/10.4330/wjc.v5.i5.132