Trend in prevalence of uncontrolled total serum cholesterol for cardio-cerebro-vascular disease in a mediterranean area, 1988/89-2008/09

Table 1 Mean ± SD of cholesterol, high density-cholesterol, low density lipoprotein-cholesterol and triglycerides

	Age (yr)	Cholesterol (mg/dL)	HDL-C (mg/dL)	LDL-C (mg/dL)	Triglycerides (mg/dL)
Male	25-34	191.9 ± 41.6	45.1 ± 10.1	125.2 ± 35.5	114.6 ± 78.9
	35-44	206.8 ± 39.7	48.4 ± 12.5	131.3 ± 35	136.7 ± 77.3
	45-54	197.9 ± 40	55.7 ± 13.9	117.8 ± 34.6	122.2 ± 70.9
	55-64	195.6 ± 31.6	49.4 ± 12.6	120.2 ± 31.9	130.2 ± 62.7
	65-74	196 ± 45.5	52.4 ± 12.4	119.5 ± 39	118.9 ± 69.9
	25-741	197.9 ± 40.2	50 ± 12.3	123.3 ± 34.9	124.9 ± 72.6
Female	25-34	201.1 ± 37.6	47.8 ± 11.4	131.0 ± 34.7	111.5 ± 71.7
	35-44	206.7 ± 41.4	52.5 ± 14.9	130.3 ± 37.7	119.6 ± 65.3
	45-54	203.7 ± 38.3	59.7 ± 13.7	120.9 ± 33.1	115.8 ± 72.7
	55-64	206.2 ± 38.8	52.4 ± 12.7	125.3 ± 34.2	142.6 ± 74.7
	65-74	195.6 ± 41.4	51.9 ± 12.4	119.8 ± 34.7	119.2 ± 67.1
	25-741	203.3 ± 39.3	53.0 ± 13.1	126.1 ± 34.9	121.0 ± 70.5

¹Data standardized to the European population. VIP Study 2008/09 (120 subjects by age group). HDL: High density lipoprotein; LDL: Low density lipoprotein.

Table 2 Percentiles of cholesterol, high density-cholesterol, low density lipoprotein-cholesterol and triglycerides (mg/dL) for both sexes

Percentiles	Cholesterol		LDL-C		HDL-C		Triglycerides
	M	F	M	F	M	F	M	F
5°	136	137	70	70	32	34	47	49
25°	169	175	98	101	40	43	75.5	76
50°	196.5	201	121	123.5	49	52	105.5	104.5
75°	222	229.5	143	146.5	57	60	151	145
95°	267	270	189.5	182.5	72.5	79.5	256	235

M: Male; F: Female. HDL: High density lipoprotein; LDL: Low density lipoprotein.

Table 3 Prevalence of ipercholesterolaemia

	Group1 1988-89	Group2 1998-99	Group3 2008-09	P value	1 vs 3	1 vs 2	2 vs 3
	(n = 522)	(n = 600)	(n = 600)
Male
Uncontrolled high cholesterol (≥ 240 mg/dL)	20.80%	14.30%	13.9%	0.002	< 0.05	< 0.05	NS
Hypercholesterolemia	20.80%	16.40%	21.1%	NS
Treated hypercholesterolaemia	-	2.50%	40.8%	0.000
Treated to target	-	84%	91.0%	0.000
Hypercholesterolaemia to target	-	12.80%	37%	0.000
Female
Uncontrolled high cholesterol (≥ 240 mg/dL)	19.90%	18.20%	18.1%	0.007	< 0.05	< 0.05	NS
Hypercholesterolemia	19.90%	18.90%	25.8%	NS
Treated hypercholesterolaemia	-	7.90%	39.1%	0.000
Treated to target	-	46.70%	80.2%	0.000
Hypercholesterolaemia to target	-	3.70%	37%	0.000

Data standardized to the European population; Men and women. Uncontrolled high cholesterol (≥ 240 mg/dL): Subjects with Cholesterolaemia ≥ 240 mg/dL, may or may not have been taking medication; Hypercholesterolemia: Subjects with cholesterol ≥ 240 + cholesterol-lowering therapy subjects; Treated hypercholesterolaemia: Treated/Hypercholesterolemia; Treated to target: Treated to target (cholesterol < 240 mg/dL)/all subjects treated; Hypercholesterolaemia to target: (Hypercholesterolemia < 240 mg/dL/subject with hypercholesterolemia). NS: Non-significant.