Effect of eicosapentaenoic acid on regional arterial stiffness: Assessment by tissue Doppler imaging

Table 1 Clinical data before and after eicosapentaenoic acid administration (n = 19)

Variables	Pre-administration	After-administration	P value
Systemic hypertension	17 (89%)	17 (89%)	NS
Dyslipidemia	14 (74%)	14 (74%)	NS
Body mass index (kg/m2)	23.9 ± 2.3	23.9 ± 2.5	NS
Systolic BP (mmHg)	131 ± 16	130 ± 13	NS
Diastolic BP (mmHg)	83 ± 9	80 ± 7	NS
Triglyceride (mg/dL)	107 ± 52	99 ± 24	NS
LDL cholesterol (mg/dL)	114 ± 29	108 ± 28	NS
EPA (%)	3.0 ± 1.1	8.5 ± 2.9	< 0.001

Values are given as mean ± SD or number (percentage). BP: Blood pressure; LDL: Low-density-lipoprotein; NS: Not significant.

Table 2 Echocardiographic data before and after eicosapentaenoic acid administration (n = 19, mean ± SD)

Variables	Pre-administration	After-administration	P value
LA dimension (mm)	38 ± 5	39 ± 4	NS
LVDd (mm)	48 ± 3	48 ± 4	NS
LVDs (mm)	29 ± 4	30 ± 5	NS
Mitral E/A	0.96 ± 0.28	1.01 ± 0.56	NS
Mitral DT (ms)	218 ± 44	232 ± 60	NS
LV ejection fraction (%)	76 ± 8	76 ± 9	NS
Strain rate of aorta (/s)	19.2 ± 5.6	23.0 ± 6.6	< 0.05

LA: Left atrial; LVDd: Left ventricular end-diastolic dimension; LVDs: Left ventricular end-systolic dimension; DT: Deceleration time; NS: Not significant.