Renin and cardiovascular disease: Worn-out path, or new direction

doi:10.4330/wjc.v3.i3.72

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Mar 26, 2011 (publication date) through Nov 29, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Mar 26, 2011; 3(3): 72-83
Published online Mar 26, 2011. doi: 10.4330/wjc.v3.i3.72

Table 1 Effect of commonly used antihypertensives on effectors of the renin-angiotensin system

	PRC	PRA	Ang I	Ang II	Ang III	Ang IV	Ang-(1-7)
ACE-I	↑	↑	↑	↓	↓	↑	↑
ARB	↑	↑	↑	↓	↑	↓	↑
DRI	↑	↓	↓	↑	↓	↓	↓
Diuretics	↑	↑	↑	↑	Not known	Not known	↑¹/Not known
CCB	↔	↔	↔	↔	Not known	Not known	Not known
β blockers	↓	↓	↓	↓	Not known	Not known	↓²/Not known

¹Effect shown with hydrochlorothiazide only;

²Effect shown with propanolol only. PRC: Plasma renin concentration; PRA: Plasma renin activity; Ang: Angiotensin; ACE-I: Angiotensin converting enzyme inhibitors; ARB: Angiotensin receptor blockers; DRI: Direct renin inhibitors; CCB: Calcium channel blockers.

Citation: Alreja G, Joseph J. Renin and cardiovascular disease: Worn-out path, or new direction. World J Cardiol 2011; 3(3): 72-83
URL: https://www.wjgnet.com/1949-8462/full/v3/i3/72.htm
DOI: https://dx.doi.org/10.4330/wjc.v3.i3.72