Current status of aggressive blood pressure control

Table 1 Clinical trials demonstrating a J-curve effect for myocardial infarction, but not for stroke

Author	Subjects	Age (yr)	Follow-up (yr)	Baseline (DBP mmHg)	CAD (present)	J-curve event
						MI	Stroke	DBP (mmHg)
Messerli et al[9]	22 576	66	2.7	86	Yes	Yes	No	76-86
Sleight et al[10]	25 620	55	4.7	82	Yes	Yes	No	75-79
Stewart et al[11]	169	44	6.3	124	No	Yes	-	100-109
Cruickshank et al[12]	902	55	6.1	109	Yes	Yes	No	80-90
Waller et al[13]	3350	50	6.5	110	Yes	Yes	-	91-98
Fletcher et al[18]	2145	51	4.0	107	Yes	Yes	No	86-91
Alderman et al[19]	1765	51	4.2	102	Yes	Yes	No	84-88
Samuelsson et al[20]	686	52	12.0	106	Yes	Yes	No	81
McCloskey et al[21]	912	30-79	3-21	104	Yes	Yes	No	84
Lindblad et al[22]	2574	59	7.4	92	Yes	Yes	No	84
Pastor-Barriuso et al[23]	7830	54	15.0	82	No	Yes	No	80
Protogerou et al[24]	331	85	3-4	-	Yes	Yes	No	< 70
Fagard et al[25]	4695	70	1-8	85	Yes	Yes	No	70-75

CAD: Coronary artery disease; DBP: Diastolic blood pressure; MI: Myocardial infarction.

Table 2 Clinical trials without clear evidence of J-curve effect

Author	Subjects	Age (yr)	Follow-up (yr)	Baseline (DBP mmHg)	CAD (present)	J-curve effect MI	Stroke	DBP (mmHg)
Wilhelmsen et al[26]	6569	40-60	3.9	107	Yes	Yes2	No	88-89
Coope et al[27]	884	60-79	4.4	98	Yes	Yes1	No	80-89
Lubsen et al[29]	7661	63.0	4.9	85	Yes	Yes3	No	85
Psaty et al[30]	4702	72.6	6.7	71	No	No	No	62
Glynn/PHS[31]	22 071	53.2	13.0	79	Yes	No	No	65
Glynn/WHS[31]	39 876	53.8	6.2	78	No	No	No	70

¹Present in female smokers;

²Present for trend;

³Present for trend. CAD: Coronary artery disease; DBP: Diastolic blood pressure; MI: Myocardial infarction.