Angiotensin-converting enzyme and bradykinin gene polymorphisms and cough: A meta-analysis

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Oct 26, 2011 (publication date) through Jul 19, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Oct 26, 2011; 3(10): 329-336
Published online Oct 26, 2011. doi: 10.4330/wjc.v3.i10.329

Table 1 Distribution of genotypes and allelic frequencies of ACE and bradykinin B₂ receptor polymorphisms in patients with or without cough

	Population	Studies		Genotype			χ²test	Studies	Allele		Odds ratio(95% CI)
				I/I	I/D	D/D			I	D	Odds ratio(95% CI)
Angiotensin converting enzyme	All	11	Cough (-)	390 (32)	571 (48)	241 (20)	0.004	7	0.51	0.49	1.26 (0.99-1.61)
			Cough (+)	338 (39)	381 (44)	142 (17)			0.45	0.55	1.26 (0.99-1.61)
	Caucasians	3	Cough (-)	75 (24)	132 (43)	100 (33)	0.230	2	0.53	0.47	0.72 (0.46-61.4)
			Cough (+)	23 (19)	51 (41)	50 (40)			0.61	0.39	0.72 (0.46-61.4)
	East Asians	8	Cough (-)	315 (35)	439 (49)	141 (16)	0.005	5	0.49	0.51	1.49 (1.11-12.02)
			Cough (+)	315 (43)	330 (45)	92 (12)			0.39	0.61	1.49 (1.11-12.02)
				T/T	T/C	C/C			C	T
B2 receptor B₂ receptor -58T/C	East Asians	3	Cough (-)	145 (26)	270 (50)	143 (24)	0.015	2	0.56	0.44	2.25 (1.42-23.57)
B2 receptor B₂ receptor -58T/C			Cough (+)	139 (30)	244 (52)	85 (18)			0.36	0.64	2.25 (1.42-23.57)

Table 2 Odds ratios and heterogeneity results for the genetic contrasts of ACE I/D and bradykinin B₂ receptor gene polymorphisms

	Genetic contrast	Population	Studies	Random effects [OR (95% CI)]	P value Q test	Z
Angiotensin converting enzyme	D vs I	All	7	1.15 (0.87-1.52)	0.259	0.231
		Caucasians	2	0.90 (0.60-1.35)	0.799	0.612
		East Asians	5	1.49 (1.11-2.02)	0.226	0.009
	DD vs (DI + II)	All	11	0.85 (0.67-1.06)	0.005	0.153
		Caucasians	3	1.14 (0.74-1.76)	0.716	0.563
		East Asians	8	0.76 (0.58-0.99)	0.003	0.042
	(DD + II) vs II	All	11	1.22 (0.91-1.64)	0.052	0.133
		Caucasians	3	0.84 (0.46-1.55)	0.560	0.553
		East Asians	8	1.35 (0.91-2.00)	0.027	0.075
	DD vs II	All	11	0.79 (0.62-1.01)	0.008	0.058
		Caucasians	3	1.12 (0.69-1.83)	0.614	0.626
		East Asians	8	0.70 (0.53-0.93)	0.006	0.013
	ID vs (DD + II)	All	11	0.95 (0.80-1.22)	0.936	0.354
		Caucasians	3	0.97 (0.63-1.50)	0.889	0.900
		East Asians	8	0.94 (0.79-1.13)	0.786	0.342
Bradykinin B₂ receptor -58T/C	T vs C	East Asians	2	2.29 (1.42-3.68)	0.298	0.001
	TT vs (TC + CC)	East Asians	3	1.47 (0.56-3.85 )	0.002	0.467
	CC vs (TC + TT)	East Asians	3	0.90 (0.66-1.24)	0.661	0.507
	TC vs (TT + CC)	East Asians	3	1.08 (0.87-1.34)	0.947	0.477

Citation: Nishio K, Kashiki S, Tachibana H, Kobayashi Y. Angiotensin-converting enzyme and bradykinin gene polymorphisms and cough: A meta-analysis. World J Cardiol 2011; 3(10): 329-336
URL: https://www.wjgnet.com/1949-8462/full/v3/i10/329.htm
DOI: https://dx.doi.org/10.4330/wjc.v3.i10.329