Assessment of right ventricular afterload by pressure waveform analysis in acute pulmonary hypertension

doi:10.4330/wjc.v3.i10.322

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Oct 26, 2011 (publication date) through Dec 30, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Oct 26, 2011; 3(10): 322-328
Published online Oct 26, 2011. doi: 10.4330/wjc.v3.i10.322

Table 1 Hemodynamic data (mean ± SD, n = 6)

	CTL	PPH	APH
Pm (mmHg)	14.8 ± 1.8	21.9 ± 2.7^a	21.2 ± 2.9^c
Pp (mmHg)	7.5 ± 2.4	17.8 ± 4.7^a	11.8 ± 3.5^a^c
PF (mL/s)	32.7 ± 5.0	36.4 ± 6.0	35.5 ± 5.4
HR (beats/min)	110 ± 23	111 ± 28	105 ± 19
ZO (dyne.s/cm⁵)	621 ± 49	961 ± 190^a	917 ± 180^a
ZC (dyne.s/cm⁵)	82 ± 20	167 ± 60^a	98 ± 21^c
Cp (mL/mmHg)	2.63 ± 0.9	1.16 ± 0.36^a	1.87 ± 0.37^c

CTL: Control; Cp: Capacitance index; HR: Heart rate; PPH: Passive pul-monary hypertension; APH: Active pulmonary hypertension; Pm and Pp: Mean and pulse pulmonary arterial pressure, respectively; PF: Pulmonary flow; ZO and ZC: Total and characteristic impedances, respectively.

^aP < 0.05 vs CTL;

^cP < 0.05 vs PPH.

Table 2 Indices of dynamic afterload in time domain (mean ± SD, n = 6)

	CTL	PPH	APH
Ppf (Pp/Pm)	0.53 ± 0.17	0.83 ± 0.25^a	0.56 ± 0.17^c
Pi-Pd (mmHg)	5.9 ± 1.8	9.1 ± 1.9^a	7.4 ± 2.0^a^c
Ps-Pi (mmHg)	1.8 ± 0.5	8.7 ± 3.0^a	4.3 ± 1.7^a^c
(Ps-Pi)/(Pi-Pd)	0.31 ± 0.08	0.95 ± 0.24^a	0.6 ± 0.21^a^c
AI [(Ps-Pi)/Pp]	0.25 ± 0.03	0.48 ± 0.06^a	0.37 ± 0.08^a^c
Ti (ms)	104 ± 21	50 ± 13^a	70 ± 17^a^c
Pi (mmHg)	16.2 ± 3.3	22.9 ± 4.4^a	22.1 ± 6.0^a
EW (mmHg/s)	0.6 ± 0.2	3 ± 1.1^a	1.6 ± 0.8^a^c

APH: Active pulmonary hypertension; Ps, Pd, Pi: Systolic, diastolic and inflection pulmonary arterial pressures, respectively; Ppf: fractional pulse pressure; AI: Augmentation index; Ti: Time at the inflection point; EW: Wasted energy generated by the right ventricle due to wave reflection during ejection.

^aP < 0.05 vs CTL;

^cP < 0.05 vs PPH.

Citation: Grignola JC, Domingo E, Devera L, Ginés F. Assessment of right ventricular afterload by pressure waveform analysis in acute pulmonary hypertension. World J Cardiol 2011; 3(10): 322-328
URL: https://www.wjgnet.com/1949-8462/full/v3/i10/322.htm
DOI: https://dx.doi.org/10.4330/wjc.v3.i10.322