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©2010 Baishideng Publishing Group Co.
World J Cardiol. Aug 26, 2010; 2(8): 243-250
Published online Aug 26, 2010. doi: 10.4330/wjc.v2.i8.243
Published online Aug 26, 2010. doi: 10.4330/wjc.v2.i8.243
Ref. | Study design | Subjects | Conclusion |
Kumagai et al[21] | Prospective | Interventional canine sterile pericarditis model; atorvastatin | Atorvastatin group had lower CRP, shorter duration of AF, less inflammation in atrial tissues |
Siu et al[25] | Retrospective | 62 lone persistent AF, statin vs control | Lower recurrence rate in the statin group |
Tveit et al[35] | Prospective | 114 patients undergoing electrical cardioversion; pravastatin vs none | Pravastatin did not reduce the recurrence rate of AF |
Young-Xu et al[26] | Prospective | 449 patients with CAD were followed for 5 yr | Development of AF was lower in statin group |
Ozaydin et al[24] | Prospective | 48 patients undergoing cardioversion; atorvastatin vs none | 81% relative risk reduction in AF recurrence |
Ozaydin et al[31] | Observational | 264 patients undergoing CABG surgery; any statin | Statin group had lower AF rates |
Patti et al[30] (ARMYDA-3) | Prospective | 200 patients undergoing CABG surgery; atorvastatin vs placebo | 61% reduction in the odds of AF |
García-Fernández et al[36] | Prospective | 52 patients undergoing cardioversion; atorvastatin vs none | No significant difference in recurrence rate of AF |
Ramani et al[27] | Retrospective | 1526 patients with ACS; various statins | 43% reduction in the odds |
Humphries et al[37] | Prospective, observational | 625 patiens undergoing cardioversion; any statin | 74% reduction in the odds of AF with β-blocker; no effect alone |
Hanna et al[42] | Data from a multicenter registry | 25 268 patients with LVEF ≤ 40% | Lipid-lowering drug use was associated with reduced odds of AF |
Fauchier et al[43] | Meta-analysis | Six studies with 3557 patients | Statins were significantly associated with a decreased risk of AF (P = 0.02) |
Benefit of statins was more marked in secondary prevention of AF | |||
Liu et al[44] | Meta-analysis | Six randomized and 10 observational studies with 7041 patients | No significant effect of statins on AF development (P = 0.09). Observational studies showed that statin use decrease the relative risk for AF by 23%. This effect was greatest in the postoperative patients |
Patel et al[46] | Meta-analysis | 14 trials with 7402 patients | Statin decreased AF rates by 45%. Decrease was most prominent in postoperative AF |
Marín et al[32] | Prospective, observational | 234 patients undergoing CABG surgery; any statin | 48% reduction in the odds of AF |
McLean et al[40] | Two large, randomized trials: PROVE IT-TIMI 22 and A to Z trial | 8659 patients with ACS; low- vs high-dose statin therapy | Neither study showed decreased AF risk with high-dose statin therapy |
Lertsburapa et al[33] | Observational | 555 patients undergoing CABG surgery; any statin | 40% reduction in the odds of AF |
Kourliouros et al[34] | Retrospective | 680 patients undergoing CABG surgery; atorvastatin and simvastatin | Improving benefits with higher dose |
Virani et al[39] | Retrospective | 4044 patients undergoing CABG surgery; any statin | No effect |
Adabag et al[41] | Cohort | 13 783 CAD patients | No difference in AF incidence with statin treatment (P = 0.09). However, AF was reduced in a subgroup of patients with congestive heart failure (P = 0.04) |
Ref. | Study design | Subjects | Conclusion |
Physicians’ Health Study[54] | Prospective | 17 679 patients (epidemiological study) | Although statistically insignificant, AF risk is higher in PUFAs group |
Danish study[53] | Prospective | 47 949 patients (epidemiological study) | Although statistically insignificant, AF risk is higher in PUFAs group |
Rotterdam study[55] | Prospective | 5184 patients (epidemiological study) | Although statistically insignificant, AF risk is higher in PUFAs group |
Mozaffarian et al[51] | Prospective | 4815 patients (epidemiological study) | Although statistically insignificant, AF risk is higher in fried fish/fish sandwich group |
Significantly, AF risk is lower in broiled/baked fish group | |||
Calò et al[48] | Prospective | 160 patients undergoing CABG surgery | AF risk is significantly lower in PUFAs group |
Saravanan et al[49] | Prospective | Patients undergoing CABG surgery | AF risk is significantly lower in PUFAs group |
Ref. | Study design | Subjects | Conclusion |
Chaney et al[57] | Prospective | 60 patients undergoing CABG surgery; methylprednisolone | No effects of steroids on in the incidence of AF |
Yared et al[58] | Randomized | 235 patients undergoing CABG or valve surgery | Dexamethasone decreased incidence of new-onset AF |
Yared et al[59] | Randomized | 78 patients undergoing CABG or valve surgery | Dexamethasone did not decrease incidence of new-onset AF and inflammation |
Dernellis et al[17] | Randomized | 104 patients undergoing electrical cardioversion | Methylprednisolone decreased plasma CRP levels and AF recurrence |
Goldstein et al[61] | Animal study | Canine sterile pericarditis model | Prednisone treatment decreased inflammation, and eliminated atrial arrhythmia inducibility |
Halonen et al[60] | Randomized | 241 patients undergoing CABG or valve surgery | Corticosteroids decreased the incidence of postoperative AF and serum CRP levels |
Baker et al[62] | Meta-analysis | Nine studies with 990 patients undergoing CABG or valve surgery | Positive effects of perioperative corticosteroid use on AF occurrence |
Ref. | Study design | Subjects | Conclusion |
Murray et al[76] | Prospective study, retrospective analysis | 732 patients; AF rhythm control | No difference in AF recurrence |
Madrid et al[71] | Prospective (electrical cardioversion) | 154 patients; amiodarone only vs amiodarone + irbesartan | Recurrence of AF lower in irbesartan group |
Zaman et al[73] | Prospective (electrical cardioversion) | 47 patients; ACEI vs no ACEI group | Number of defibrillation attempts required for successful cardioversion was less in ACEI group |
Ueng et al[72] | Prospective (electrical cardioversion) | 125 patients; amiodarone only vs amiodarone + enalapril | Enalapril group had decreased rate of recurrence |
Pedersen et al[65] | Prospective (post-MI) | 1577 patients with LV dysfunction post-MI; trandolapril vs control | Trandolapril reduces AF |
SOLVD[66] | Prospective study, but retrospective analysis (heart failure) | 374 patients with depressed LV function; enalapril vs control | AF rate lower in ACEI group |
Val-HeFT[78] | Prospective study, retrospective analysis (heart failure) | 4409 patients with; valsartan vs control | ARB lower incidence of AF |
CHARM[77] | Prospective study, retrospective analysis (heart failure) | 5518 patients; candesartan vs control | ARB lowers incidence of AF in both normal and depressed ejection fraction |
L'Allier et al[79] | Retrospective (hypertension) | 5463 patients receiving ACEI vs 5463 patients receiving CCB | The incidence of AF was lower in ACEI group |
Miceli et al[80] | Retrospective (post-CABG) | 10 023 patients undergoing isolated CABG; ACEI vs non-ACEI | ACEI treatment is associated with an increased risk of post-operative AF |
Madrid et al[81] | Meta-analysis | Seven trials involving a total of 24 849 patients | There was a significant statistical difference in the development AF with ACEI/ARB treatment |
Kalus et al[82] | Meta-analysis | Four trials | There was a significant statistical difference in the development AF with ACEI/ARB treatment |
Anand et al[83] | Meta-analysis | Nine randomized controlled trials | The use of ACEIs and ARBs had an overall effect of 18% risk reduction in new-onset AF across the trials and 43% risk reduction in patients with heart failure |
Jibrini et al[84] | Meta-analysis | 11 randomized trials | Overall, inhibition of the RAAS reduced the RR of AF by 19%. Reduction in AF was greatest in patients after electrical cardioversion and in patients with heart failure |
Healey et al[85] | Meta-analysis | 11 randomized trials | Overall, ACEIs and ARBs reduced the relative risk of AF by 28%. Reduction in AF was similar between ACEI and ARB and was greatest in patients with heart failure. Overall, there was no significant reduction in AF in patients with hypertension |
- Citation: Ozaydin M. Atrial fibrillation and inflammation. World J Cardiol 2010; 2(8): 243-250
- URL: https://www.wjgnet.com/1949-8462/full/v2/i8/243.htm
- DOI: https://dx.doi.org/10.4330/wjc.v2.i8.243