Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications

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Feb 26, 2025 (publication date) through Feb 25, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Feb 26, 2025; 17(2): 102308
Published online Feb 26, 2025. doi: 10.4330/wjc.v17.i2.102308

Table 1 Acid sphingomyelinase/ceramide functional inhibitors

Serial number	FIASMAs	Current functional or therapeutic disease	Potential therapeutic metabolic disease
1	Amitriptyline	Depression	Diabetic cardiomyopathy
2	Desipramine	Depression	Insulin resistance. Diabetes
3	Doxepin	Depression	Diabetes
4	Imipramine	Depression	Diabetic cardiomyopathy
5	Alpha-mangostin	Anti-cancer, antibacterial, anti-inflammation, antioxidant	Vascular endothelial injury. Cardiovascular disease
6	Empagliflozin	Diabetes	Cardiovascular disease

FIASMAs: Functional inhibitors of acid sphingomyelinase.

Citation: Wang HN, Wang Y, Zhang SY, Bai L. Emerging roles of the acid sphingomyelinase/ceramide pathway in metabolic and cardiovascular diseases: Mechanistic insights and therapeutic implications. World J Cardiol 2025; 17(2): 102308
URL: https://www.wjgnet.com/1949-8462/full/v17/i2/102308.htm
DOI: https://dx.doi.org/10.4330/wjc.v17.i2.102308