Copyright
©The Author(s) 2021.
World J Cardiol. Dec 26, 2021; 13(12): 745-757
Published online Dec 26, 2021. doi: 10.4330/wjc.v13.i12.745
Published online Dec 26, 2021. doi: 10.4330/wjc.v13.i12.745
Table 1 Patient characteristics
| Non-cardiac chest pain | ETT | ECG | Angina | Review | Lost to follow-up | Previous cardiac problems | Stress Echo (negative) | Stress Echo (positive) | Echo (negative) | Echo (pos) | CCTA (negative) | CCTA (positive) | Angiogram (negative) | Angiogram (positive) | ACS | |
| Age (yr) | 57 (23-88) | 54 (36-66) | 66 (62-69) | 73 (66-79) | 66 (43-84) | 64 (41-84) | 71 (67-87) | 63 (49-82) | 68 | 67 (43-84) | 72 (55-83) | 53 (34-63) | 62 (51-77) | 59 (50-65) | 58 (46-81) | 69 (62-86) |
| Sex (M/F) | 15/15 | 11/2 | 0/2 | 1/5 | 5/2 | 4/14 | 3/4 | 4/9 | 1/0 | 10/9 | 5/1 | 4/8 | 5/5 | 3/3 | 12/5 | 2/3 |
| BMI (> 25 kg/m2) (n) | 9 | 4 | 1 | 2 | 4 | 8 | 0 | 2 | 1 | 4 | 0 | 4 | 5 | 1 | 6 | 2 |
| Diabetes (n) | 2 | 4 | 0 | 1 | 2 | 1 | 0 | 2 | 0 | 2 | 2 | 2 | 1 | 0 | 4 | 3 |
| Hyperlipidmia (n) | 11 | 8 | 1 | 2 | 4 | 6 | 4 | 6 | 1 | 11 | 5 | 5 | 7 | 2 | 11 | 3 |
| Hypertension (n) | 10 | 7 | 2 | 4 | 4 | 7 | 3 | 7 | 1 | 13 | 5 | 4 | 8 | 3 | 11 | 2 |
| Family History of CAD (n) | 6 | 5 | 1 | 0 | 3 | 7 | 0 | 3 | 0 | 5 | 2 | 8 | 6 | 3 | 10 | 0 |
| Smoker (n) | 11 | 5 | 0 | 4 | 5 | 9 | 1 | 6 | 0 | 10 | 4 | 3 | 9 | 1 | 8 | 0 |
| Past History MI/stent/CABG (n) | 2 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Aspirin (n) | 7 | 2 | 0 | 2 | 1 | 6 | 3 | 4 | 0 | 4 | 2 | 4 | 5 | 2 | 6 | 2 |
| Statin (n) | 5 | 3 | 0 | 2 | 1 | 3 | 5 | 3 | 1 | 7 | 4 | 1 | 2 | 0 | 10 | 1 |
| ISMN/Nitroglycerin (n) | 9 | 1 | 1 | 5 | 3 | 6 | 4 | 7 | 1 | 7 | 3 | 4 | 5 | 3 | 8 | 2 |
| Anti-hypertensive (n) | 7 | 7 | 1 | 2 | 3 | 2 | 5 | 4 | 1 | 8 | 4 | 2 | 1 | 1 | 14 | 2 |
| Creatinine (µmol/L) (n) | 83 (52-122) | 79 (54-100) | 77 (71-82) | 83 (70-103) | 82 (51-98) | 75 (47-109) | 71 (36-95) | 72 (56-88) | 84 | 78 (52-102) | 83 (63-103) | 71 (52-88) | 72 (52-99) | 78 (56-98) | 81 (46-134) | 76 (65-86) |
| QRISK3% | 2-> 88 | 12 (7-40) | 9 (5-13) | 22 (6-34) | 22-41 | 19 (2-58) | NA | 13 (3-36) | 32 | 1 to > 40 | 12 to 45 | 9.4 (1-35) | 22 (6-37) | 8 (2-16) | 8 to > 40 | |
| n | 30 | 13 | 2 | 6 | 7 | 18 | 7 | 13 | 1 | 19 | 6 | 12 | 10 | 6 | 17 | 5 |
Table 2 uscTnI values by patient subgroup according further testing following clinical review
| Subgroup | uscTnI ng/L (minimum value) | uscTnI ng/L (average value) | uscTnI ng/L (maximum value) | n | P value |
| Referred back to the community practitioner (non-cardiac chest pain) | 0.71 | 2.9 | 17 | 30 | |
| Exercise test | 0.97 | 2.6 | 9.7 | 13 | |
| 24 h ECG | 1.9 | 2.3 | 2.6 | 2 | |
| Diagnosed angina, treated with medication | 1.8 | 5.0 | 9.2 | 6 | |
| Advised further review by specialist cardiologist | 1.0 | 12 | 70 | 7 | |
| Lost to follow up | 0.8 | 2.6 | 7.5 | 18 | |
| Previously diagnosed with cardiac problems and under the care of a cardiologist | 1.5 | 7.2 | 33.2 | 7 | |
| Echo (normal) | 0.46 | 3.0 | 8.6 | 19 | |
| Echo (mild abnormalities) | 2.47 | 6.44 | 17.0 | 6 | |
| Stress echo (negative) | 0.98 | 2.1 | 3.9 | 13 | |
| Stress echo(positive) | 3.1 | 3.1 | 3.1 | 1 | |
| CCTA (negative) | 0.58 | 2.8 | 9.3 | 12 | NS |
| CCTA (positive) | 1.1 | 2.7 | 8.7 | 10 | |
| Angiogram(negative) | 1.1 | 1.8 | 2.2 | 6 | < 0.05 |
| Angiogram(positive) | 0.94 | 7.3 | 49 | 17 |
Table 3 Patients assigned to coronary angiogram
| Group | Normal | Mild disease | Moderate disease | Severe disease |
| Mean uscTnI ng/L | 1.8 | 3.3 | 7.3 | 10 |
| Min uscTnI ng/L | 1.1 | 2.0 | 1.0 | 0.94 |
| Max uscTnI ng/L | 2.2 | 3.9 | 22 | 49 |
| n | 6 | 5 | 5 | 7 |
- Citation: Ramasamy I. Highly sensitive troponin I assay in the diagnosis of coronary artery disease in patients with suspected stable angina. World J Cardiol 2021; 13(12): 745-757
- URL: https://www.wjgnet.com/1949-8462/full/v13/i12/745.htm
- DOI: https://dx.doi.org/10.4330/wjc.v13.i12.745