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Copyright ©The Author(s) 2020.
World J Cardiol. Jul 26, 2020; 12(7): 334-341
Published online Jul 26, 2020. doi: 10.4330/wjc.v12.i7.334
Table 1 Basic characteristics of different types of left ventricular assist devices
Type of LVADExamplePump designCharacteristicsHemolysis
First-generationHeartMate IPulsatile flowLarger blood contacting surfaces, multiple moving partsIncrease
Second-generationHeartMate IIContinuous – axial flowSmaller sizeIncrease
Third-generationHeartWareContinuous – centrifugal flowNoncontact bearing (magnetic levitation)Increase
Table 2 Baseline characteristics, demographics and results of studies investigating hemolysis in left ventricular assist devices
Ref.Study designDeviceNo of patientsDefinition of hemolysisOutcomeResulta
Xia et al[37], 2019Retrospective (data obtained from the INTERMACS registry 2012-2013)Continuous flow LVADs1116NAShort-term survival (< 3 yr)aOR: 3.57 (1.84-6.93)
Katz et al[5], 2015Retrospective (data obtained from the INTERMACS registry 2006-2012)Continuous flow LVADs4850PfHg > 40 mg/dL and clinical signs of hemolysisMortality (mean of follow-up: 11.1 mo)OR: 1.19 (1.146-2.52)
Ravichandran et al[10], 2014RetrospectiveHeartMate II100Hgb < 10 g/dL, haptoglobin < 8 g/dL and LDH > 250 U/L1-yr mortalityOR: 11.3 (3.56-35.93)
Cowger et al[30], 2014RetrospectiveHeartMate II182SfHg > 40 mg/dL and clinical signs of hemolysis1-yr mortalityHR: 4.3 (2.1-8.9)