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©The Author(s) 2020.
World J Cardiol. Jul 26, 2020; 12(7): 334-341
Published online Jul 26, 2020. doi: 10.4330/wjc.v12.i7.334
Published online Jul 26, 2020. doi: 10.4330/wjc.v12.i7.334
Table 1 Basic characteristics of different types of left ventricular assist devices
Type of LVAD | Example | Pump design | Characteristics | Hemolysis |
First-generation | HeartMate I | Pulsatile flow | Larger blood contacting surfaces, multiple moving parts | Increase |
Second-generation | HeartMate II | Continuous – axial flow | Smaller size | Increase |
Third-generation | HeartWare | Continuous – centrifugal flow | Noncontact bearing (magnetic levitation) | Increase |
Table 2 Baseline characteristics, demographics and results of studies investigating hemolysis in left ventricular assist devices
Ref. | Study design | Device | No of patients | Definition of hemolysis | Outcome | Resulta |
Xia et al[37], 2019 | Retrospective (data obtained from the INTERMACS registry 2012-2013) | Continuous flow LVADs | 1116 | NA | Short-term survival (< 3 yr) | aOR: 3.57 (1.84-6.93) |
Katz et al[5], 2015 | Retrospective (data obtained from the INTERMACS registry 2006-2012) | Continuous flow LVADs | 4850 | PfHg > 40 mg/dL and clinical signs of hemolysis | Mortality (mean of follow-up: 11.1 mo) | OR: 1.19 (1.146-2.52) |
Ravichandran et al[10], 2014 | Retrospective | HeartMate II | 100 | Hgb < 10 g/dL, haptoglobin < 8 g/dL and LDH > 250 U/L | 1-yr mortality | OR: 11.3 (3.56-35.93) |
Cowger et al[30], 2014 | Retrospective | HeartMate II | 182 | SfHg > 40 mg/dL and clinical signs of hemolysis | 1-yr mortality | HR: 4.3 (2.1-8.9) |
- Citation: Papanastasiou CA, Kyriakoulis KG, Theochari CA, Kokkinidis DG, Karamitsos TD, Palaiodimos L. Comprehensive review of hemolysis in ventricular assist devices. World J Cardiol 2020; 12(7): 334-341
- URL: https://www.wjgnet.com/1949-8462/full/v12/i7/334.htm
- DOI: https://dx.doi.org/10.4330/wjc.v12.i7.334