Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports

doi:10.4330/wjc.v10.i3.15

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Mar 26, 2018 (publication date) through Jul 24, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Cardiol. Mar 26, 2018; 10(3): 15-20
Published online Mar 26, 2018. doi: 10.4330/wjc.v10.i3.15

Table 1 Time course of frequency of chest pain and cardiovascular drug regimen in Case 1

Time course	Frequency of chest pain	Cardiovascular drug regimen
Discharge	None	Diltiazem hydrochloride (brand-name) 100 mg capsule, BID
Discharge	None	Pitavastatin calcium (brand-name) 2 mg tablet, QD
10 mo later	4/mo	Diltiazem hydrochloride (brand-name) 100 mg capsule, BID
		Pitavastatin calcium (brand-name) 2 mg tablet, QD
		Isosorbide dinitrate (brand-name) 40 mg tape, QD
11 mo later	None, but nausea (+)	Benidipine hydrochloride (brand-name) 4 mg tablet, QD
11 mo later	None, but nausea (+)	Pitavastatin calcium (brand-name) 2mg tablet, QD
12 mo later	None	Benidipine hydrochloride (brand-name) 4 mg tablet, QD
12 mo later	None	Pitavastatin calcium (brand-name) 2 mg tablet, QD
14 mo later	None	Benidipine hydrochloride (generic) 4 mg tablet, QD
14 mo later	None	Pitavastatin calcium (brand-name) 2 mg tablet, QD
15 mo later	4-5/mo	Benidipine hydrochloride (brand-name) 4 mg tablet, QD
15 mo later	4-5/mo	Pitavastatin calcium (brand-name) 2 mg tablet, QD
Thereafter	None	Benidipine hydrochloride (brand-name) 4 mg tablet, QD
Thereafter	None	Pitavastatin calcium (brand-name) 2 mg tablet, QD

Table 2 Time course of frequency of chest pain and cardiovascular drug regimen in Case 2

Time course	Frequency of chest pain	Cardiovascular drug regimen
Several months ago		Diltiazem hydrochloride (brand-name) 100 mg capsule, BID
		Isosorbide dinitrate (brand-name) 20 mg capsule, BID
		Isosorbide dinitrate (brand-name) 40 mg tape, QD
		Verapamil hydrochloride (brand-name) 80 mg tablet, at bedtime
		Sarpogrelate hydrochloride (generic) 100mg tablet, BID
	1/wk	Rousvastatin calcium (brand-name) 20 mg tablet, QD
		Ezetimibe (brand-name) 10 mg tablet, QD
		Ethil isosapentate (generic) 900 mg capsule, QD
Several months ago, admission		Diltiazem hydrochloride (generic) 100 mg capsule, BID
		Isosorbide dinitrate (brand-name) 20 mg capsule, BID
		Isosorbide dinitrate (brand-name) 40 mg tape, QD
		Verapamil hydrochloride (brand-name) 80 mg tablet, at bedtime
		Sarpogrelate hydrochloride (generic) 100 mg tablet, BID
		Rousvastatin calcium (brand-name) 20 mg tablet, QD
		Ezetimibe (brand-name) 10 mg tablet, QD
		Ethil isosapentate (generic) 900 mg capsule, QD
	3-4/wk
Thereafter		Diltiazem hydrochloride (brand-name) 100 mg capsule, BID
		Isosorbide dinitrate (brand-name) 20 mg capsule, BID
		Isosorbide dinitrate (brand-name) 40 mg tape, QD
		Verapamil hydrochloride (brand-name) 80 mg tablet, at bedtime
		Sarpogrelate hydrochloride (generic) 100 mg tablet, BID
		Rousvastatin calcium (brand-name) 20 mg tablet, QD
		Ezetimibe (brand-name) 10 mg tablet, QD
	1/wk	Ethil isosapentate (generic) 900 mg capsule, QD

Citation: Goto-Semba R, Fujii Y, Ueda T, Oshita C, Teragawa H. Increased frequency of angina attacks caused by switching a brand-name vasodilator to a generic vasodilator in patients with vasospastic angina: Two case reports. World J Cardiol 2018; 10(3): 15-20
URL: https://www.wjgnet.com/1949-8462/full/v10/i3/15.htm
DOI: https://dx.doi.org/10.4330/wjc.v10.i3.15