Published online Aug 26, 2020. doi: 10.4330/wjc.v12.i8.419
Peer-review started: February 28, 2020
First decision: April 25, 2020
Revised: May 13, 2020
Accepted: August 1, 2020
Article in press: August 1, 2020
Published online: August 26, 2020
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Statins have an important and well-established role in the prevention of atherosclerotic cardiovascular disease (ASCVD). However, several studies have reported widespread underuse of statins in various practice settings and populations. Review of relevant literature reveals opportunities for improvement in the implementation of guideline-directed statin therapy (GDST).
To examine the impact of cardiologist intervention on the use of GDST in the ambulatory setting.
Patients with at least one encounter at the adult Internal Medicine Clinic (IMC) and/or Cardiology Clinic (CC), who had an available serum cholesterol test performed, were evaluated. The 2 comparison groups were defined as: (1) Patients only seen by IMC; and (2) Patients seen by both IMC and CC. Patients were excluded if variables needed for calculation of ASCVD risk scores were lacking, and if demographic information lacked guideline-directed treatment recommendations. Data were analyzed using student t-tests or χ2, as appropriate. Analysis of Variance was used to compare rates of adherence to GDST.
A total of 268 patients met the inclusion criteria for this study; 211 in the IMC group and 57 in the IMC-CC group. Overall, 56% of patients were female, mean age 56 years (± 10.65, SD), 22% Black or African American, 56% Hispanic/Latino, 14% had clinical ASCVD, 13% current smokers, 66% diabetic and 63% hypertensive. Statin use was observed in 55% (n = 147/268) of the entire patient cohort. In the IMC-CC group, 73.6% (n = 42/57) of patients were prescribed statin therapy compared to 50.7% (n = 107/211) of patients in the IMC group (P = 0.002). In terms of appropriate statin use based on guidelines, there was no statistical difference between groups [IMC-CC group 61.4% (n = 35/57) vs IMC group, 55.5% (n = 117/211), P = 0.421]. Patients in the IMC-CC group were older, had more cardiac risk factors and had higher proportions of non-white patients compared to the IMC group (P < 0.02, all).
Although overall use of GDST was suboptimal, there was no statistical difference in appropriate statin use based on guidelines between groups managed by general internists alone or co-managed with a cardiologist. These findings highlight the need to design and implement strategies to improve adherence rates to GDST across all specialties.
Core tip: Statins have an important and well-established role in the prevention of atherosclerotic cardiovascular disease. However, several studies have reported widespread underuse of statins in various practice settings and populations. Review of relevant literature reveals opportunities for improvement in the implementation of guideline-directed statin therapy (GDST). We aimed to examine the impact of cardiologist intervention on adherence to GDST in the ambulatory setting. Our evaluation shows that although overall adherence to GDST was suboptimal, there was no statistical difference in appropriate statin use based on guidelines between groups managed by general internists alone or co-managed with a cardiologist. These findings highlight the need to design and implement strategies to improve adherence rates to GDST across all specialties.
- Citation: Cassagnol M, Hai O, Sherali SA, D’Angelo K, Bass D, Zeltser R, Makaryus AN. Impact of cardiologist intervention on guideline-directed use of statin therapy. World J Cardiol 2020; 12(8): 419-426
- URL: https://www.wjgnet.com/1949-8462/full/v12/i8/419.htm
- DOI: https://dx.doi.org/10.4330/wjc.v12.i8.419
Statins have an important and well-established role in the prevention of atherosclerotic cardiovascular disease (ASCVD). Large-scale clinical trials have shown that statins substantially reduce cardiovascular morbidity and mortality in both primary and secondary prevention. The American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD Risk in Adults emphasizes identifying and treating individuals at the highest risk for developing ASCVD with statins[1,2]. However, despite mounting evidence supporting its use, several studies have reported widespread underuse of statins in the ambulatory setting[3], in secondary prevention[4], and more frequently among women[5], older adults, Blacks, Hispanics/Latinos, and those who are under/un-insured[6]. Early skepticism of the feasibility of implementing the ACC/AHA guidelines in a patient population has been documented. One report found 56% predicted prescriber adherence to those guidelines in a retrospective simulated analysis of a large academic medical practice[6]. In a more recent study, one-third of patients with ASCVD and almost one-half of patients without ASCVD were not receiving guideline recommended moderate- to high-intensity statin therapy in cardiology practices after the publication of the 2013 ACC/AHA guideline[1]. The most recent cholesterol 2018 guidelines from ACC/AHA continue to emphasize the use of statins as a primary treatment modality for eligible patients to achieve appropriate low-density lipoprotein cholesterol (LDL-C) reduction[2].
Limited information is available regarding the appropriate implementation of the cholesterol guidelines as they pertain to evidence-based statin use. The objective of our study was to examine physician adherence to GDST in the ambulatory setting across multiple subgroups of patients and determine the impact of cardiologist intervention on GDST.
A retrospective chart review was conducted of patients who had at least one encounter at the adult Internal Medicine Clinic (IMC) and/or Cardiology Clinic (CC) at our community tertiary care teaching hospital from May 2016 to April 2017 and who had an available serum cholesterol test performed. Patients were excluded if the following biometric variables needed for calculation of ASCVD risk score were unavailable: age, sex, race, systolic blood pressure (SBP), total cholesterol (TC), LDL-C, high density lipoprotein cholesterol (HDL-C), history of diabetes mellitus (DM), smoking status, and hypertension treatment status. In addition, patients whose demographics lacked guideline directed treatment recommendations were excluded (e.g., age < 40 or > 79 years). The 2 comparison groups were defined as: (1) Patients only seen by IMC; and (2) Patients seen by both IMC and CC.
The presence of clinical ASCVD included history of acute coronary syndrome, history of myocardial infarction, stable or unstable angina, coronary or other arterial revascularization, stroke, transient ischemic attack, or peripheral artery disease. Moderate- and high-intensity statin was defined by statin dose that would lower LDL-C on average by 30%-49% and ≥ 50% with daily dosing, respectively. Statin therapy utilized was categorized as appropriate or not appropriate GDST. As such, the presence of clinical ASCVD or LDL-C greater than 190 mg/dL, would indicate use of high-intensity satin (atorvastatin 40–80 mg or equivalent)[1]. For primary prevention, the presence of a diagnosis of DM and/or ASCVD risk score > 7.5% would indicate the use of at least a moderate-intensity statin (atorvastatin 10-20 mg or equivalent) depending on patient tolerance[1].
Data collected included date of visit, date of lipid panel referenced, gender, age, body mass index, race/ethnicity, TC, HDL-C, SBP, hypertension and its treatment status, presence of clinically diagnosed DM, smoking status, history of ASCVD, clinically diagnosed hyperlipidemia and current statin use including type and dose/intensity. Data were entered into the ASCVD risk calculator, with 10-Year and lifetime ASCVD risk recorded. Treatment assigned by the physician at the last clinic visit was then compared to guideline recommended treatment, and labeled as appropriate or inappropriate. If a patient’s LDL-C was greater than 190 mg/dL or if they had clinical ASCVD, then they would be eligible for high-intensity statin and use of the ASCVD risk calculator was not indicated and therefore not calculated, as per guideline recommendations.
Descriptive statistics are presented as mean ± SD or number and percent. Baseline characteristics of subgroups were compared using student t-tests or χ2 tests, as appropriate. χ2 test analysis was used to analyze statistical significance between groups. Analysis of variance was used to test the statistical difference between means of continuous variables. Statistical significance was defined as P < 0.05. All statistical analyses were performed using SPSS version 26.0 (SPSSTM Inc., Chicago, IL, United States).
A total of 268 patients met the inclusion criteria for this study. Table 1 describes the demographic characteristics of the study population, 56% were female, mean age was 56 years (± 10.65, SD), 22% identified as Black or African American and 56% identified as Hispanic/Latino. Approximately 14% of the cohort had clinical ASCVD as previously defined, 13% were current smokers, 66% were diabetic, and 63% were hypertensive. Statin use was observed in 55% of the entire cohort, with moderate- intensity statins being the most commonly prescribed.
Patient characteristics | Data |
Age (yr), mean | 56 (± 10.65, SD) |
Sex | |
Male | 118 (44) |
Female | 150 (56) |
Race | |
White | 180 (67.2) |
Black | 60 (22.2) |
Other | 28 (10.4) |
Ethnicity | |
Hispanic/Latin-o,-a | 151 (56.3) |
Smoker | |
Never | 184 (68.7) |
Former | 48 (17.9) |
Current | 34 (12.7) |
Unknown | 2 (0.7) |
ASCVD | 38 (14.2) |
mean ASCVD score | 12.1% |
Diabetes | 177 (66) |
Hypertension | 171 (63.8) |
Statin prescribed | 149 (55) |
Low | 11 (4.1) |
Moderate | 82 (30.6) |
High | 56 (20.9) |
Clinical laboratory profile | |
TC (mg/dL), mean | 200.63 (46.7, SD) |
LDL-C (mg/dL), mean | 121.08 (36.9, SD) |
HDL-C (mg/dL), mean | 51.17 (15.2, SD) |
SBP (mmHg), mean | 132 (19.2, SD) |
Of the total 268 patients, 211 and 57 patients were in the IMC only and IMC-CC group, respectively (Table 2). Overall, in the IMC-CC group, 73.6% (n = 42/57) of patients were prescribed statin therapy compared to 50.7% (n = 107/211) of patients in the IMC group (P = 0.002). In terms of appropriate statin use based on guidelines, there was no statistical difference between groups [IMC-CC group 61.4% (n = 35/57) vs IMC group, 55.5% (n = 117/211), P = 0.421]. Patients in the IMC-CC group had significantly higher cardiac risk as compared to the IMC group: Clinical ASCVD history (35.1% vs 18%, P < 0.001), diabetes (47.3% vs 30.3%, P = 0.016), hypertension (80.7% vs 59.2%, P = 0.003) and smoking history (47.4% vs 26.1%, P = 0.002). Patients in the IMC-CC group were significantly older (mean age 62.1 years vs 55.5 years, P < 0.001) and had a higher proportion of non-white patients (49.6% vs 29.4%, P = 0.021) compared to the IMC group. Mean LDL-C and TC levels were lower in the IMC-CC group vs the IMC group (mean LDL-C, 110.36 mg/dL vs 123.98 mg/dL, P = 0.013) and (TC, 187.67 mg/dL vs 204.13, P = 0.018).
All patients (n = 268) | IMC only (n = 211) | IMC/CC (n = 57) | P value |
Statin prescribed | 107 (50.7) | 42 (73) | 0.002 |
Appropriate intensity statin prescribed | 117 (55.5) | 35 (61.4) | 0.421 |
Distribution of population | |||
Age(years), mean | 55.47 (± 10.11, SD) | 62.14 (± 11.08, SD) | < 0.001 |
ASCVD | 18(8.5) | 20 (35.1) | < 0.001 |
DM | 64 (30.3) | 27 (47.3) | 0.016 |
Hypertension | 125(59.2) | 46 (80.70) | 0.003 |
Smoking history (current and former) | 55 (26.1) | 27 (47.4) | 0.002 |
Non-white | 62 (29.4) | 26 (45.6) | 0.021 |
Hispanic, Latino | 127 (60.2) | 24 (42.1) | 0.015 |
LDL-C (mg/dL), mean | 123.98 (± 34.77, SD) | 110.36 (± 42.47, SD) | 0.013 |
TC (mg/dL), mean | 204.13 (± 44.96, SD) | 187.67 (± 50.77, SD) | 0.018 |
HDL-C (mg/dL), mean | 50.4 (± 14.1, SD) | 53.9 (± 18.6, SD) | 0.126 |
In our evaluation of real-world cholesterol management, we found that adherence to GDST by physicians occurred in about half the patients eligible for statin therapy. The 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce ASCVD Risk in Adults (which were the latest available guidelines during our study period) recommends statins as first-line lipid lowering therapy for both primary and secondary prevention[7]. Furthermore, data from the National Health and Nutrition Examination Surveys estimated an increase in statin-eligible patients by 2.4 million, 2.2 million, and 8.2 million in patients with ASCVD, diabetes, and in primary prevention, respectively[8]. Given recent shifts in the cholesterol treatment paradigm from the older ATP III guidelines[9], Schoen et al[6] predicted 56% adherence with the 2013 blood cholesterol guidelines in a retrospective analysis. In another study, Pokharel et al[7] evaluated trends in the use of statin therapy and non-statin therapy in cardiology practices, before and after the publication of the 2013 ACC/AHA guidelines. They found modest, yet significant increases in the use of moderate- to high-intensity statins in ASCVD patients and no change in the other statin benefit groups and nearly half of statin eligible patients did not receive a statin[7]. By comparison, our real-world study demonstrated similar trends in that nearly half of statin eligible patients did not receive a statin. Furthermore, adherence to GDST by general internists tended to be lower (55.5%) when compared to patients who were also being managed by a cardiologist (61.4%), although this difference was not statistically significant. Hence, being evaluated by a cardiology specialist did not appear to have any additional impact on the use of GDST at our institution.
The literature also notes that different factors and patient characteristics affect implementation and use of GDST. Schoen et al[10] found that women and patients with diabetes were less likely to be treated optimally; and this in turn, could impact cardiovascular outcomes. In our study, there was a higher proportion of patients with clinical ASCVD and diabetes that were seen by the cardiologist. These patients also had lipid profiles that necessitated therapy. This may suggest that at our institution, higher risk patients needing further LDL-C reduction are appropriately being managed by cardiology specialists who are trained to address these complex situations. Furthermore, patients who were managed by the cardiologist achieved significantly lower LDL-C levels, which may translate to greater reduction in future coronary heart disease events[11]. Further long-term studies of these patients may shed light on such outcomes.
Several other studies have reported similar trends in 2013 ACC/AHA guideline implementation, however, very little is known about the barriers to adherence. Clough et al[12] found that although community-based physicians often accurately estimated risk, beliefs and approach to statin discussion varied and these variables had minimal impact on low rates of statin prescribing. An inter-professional approach using the patient-centered medical home model made no difference in guideline implementation within a primary care practice[12]. It has been well established that it may take up to 17 years for evidence to be fully implemented into practice, which may explain the low statin use in the overall study cohort[13]. More studies will need to be conducted to fully understand these barriers. However, a recent study has shown that since the publication of the 2013 ACC/AHA guidelines (and subsequent 2018 guidelines), cholesterol levels and statin use have improved in the US[14]. Future studies should be conducted to evaluate the long-term impact of the latest cholesterol guidelines on adherence to GDST[15].
Our study has several limitations including the short period of analysis, its retrospective design, and small sample size. As noted, studies have demonstrated that it may take up to 17 years for evidence to be fully implemented into practice[13], and therefore the period of analysis for our study [which occurred within 3 years (2016 to 2017) following guideline publication], may simply reflect the lag time between guideline publication and implementation. Furthermore, our study relied on the accuracy and completeness of physician documentation which may have impacted the determination of physician adherence to guideline recommendations. Our analysis does not account for other reasons why GDST was not implemented (e.g., patient factors, physician attitudes towards prescribing, adverse reactions, and cost of therapy). Additionally, our study did not account for patient adherence to prescriber recommendations. Regardless of statin treatment, we obtained information from the lipid panel which may not have impacted high-risk cohorts but underestimated statin eligibility for other cohorts (e.g., patient previously prescribed statin, but at the time of assessment patient may not have appeared to be eligible for statin therapy based on cholesterol results).
In conclusion, our study compared the use of GDST in patients managed by general internists and those co-managed by a cardiologist. As expected, patients with higher cardiac risk factors and co-morbidities were more likely to be co-managed by a cardiologist and placed on statin therapy. In terms of appropriate statin use based on guidelines, there was no statistical difference in proportion of patients receiving GDST between groups managed by general internists alone or co-managed with a cardiologist; however, there was a significantly greater use of statins in patients co-managed by a cardiologist. Overall, statin use in this population is comparable to what other studies have shown and highlights the need to design and implement strategies to improve prescriber adherence to GDST.
Statins have an important and well-established role in the prevention of atherosclerotic cardiovascular disease (ASCVD). However, several studies have reported widespread underuse of statins in various practice settings and populations.
Review of relevant literature reveals opportunities for improvement in the implementation of guideline-directed statin therapy (GDST).
In this study, we aimed to examine the impact of cardiologist intervention on the use of statin therapy in the ambulatory setting.
We conducted a retrospective chart review of patients who had at least one encounter at the adult Internal Medicine Clinic (IMC) and/or Cardiology Clinic (CC) and who had an available serum cholesterol test performed. The 2 comparison groups were defined as: (1) Patients only seen by IMC; and (2) Patients seen by both IMC and CC. Baseline characteristics of subgroups were compared.
A total of 268 patients met the inclusion criteria for this study. Approximately, 14% had clinical ASCVD, 13% were current smokers, 66% were diabetic, and 63% were hypertensive. Statin use was observed in 55% of the entire cohort, with moderate- intensity statins being the most commonly prescribed. Overall, in the IMC-CC group, 73.6% of patients were prescribed statin therapy compared to 50.7% of patients in the IMC group. There was no statistical difference in the use of GDST between groups.
Our study compared the use of GDST in patients managed by general internists and those co-managed by a cardiologist. Overall, statin use in this population is comparable to what other studies have shown and highlights the need to design and implement strategies to improve prescriber adherence to GDST.
Manuscript source: Invited manuscript
Specialty type: Cardiac and cardiovascular
Country/Territory of origin: United States
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P-Reviewer: Greenway SC S-Editor: Wang JL L-Editor: A P-Editor: Wang LL
1. | Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC, Watson K, Wilson PW; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2889-2934. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 2683] [Cited by in F6Publishing: 2957] [Article Influence: 268.8] [Reference Citation Analysis (0)] |
2. | Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella-Tommasino J, Forman DE, Goldberg R, Heidenreich PA, Hlatky MA, Jones DW, Lloyd-Jones D, Lopez-Pajares N, Ndumele CE, Orringer CE, Peralta CA, Saseen JJ, Smith SC, Sperling L, Virani SS, Yeboah J. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;139:e1082-e1143. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 678] [Cited by in F6Publishing: 1174] [Article Influence: 234.8] [Reference Citation Analysis (1)] |
3. | Persell SD, Brown T, Lee JY, Shah S, Henley E, Long T, Luther S, Lloyd-Jones DM, Jean-Jacques M, Kandula NR, Sanchez T, Baker DW. Individualized Risk Communication and Outreach for Primary Cardiovascular Disease Prevention in Community Health Centers: Randomized Trial. Circ Cardiovasc Qual Outcomes. 2015;8:560-566. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 12] [Cited by in F6Publishing: 16] [Article Influence: 1.8] [Reference Citation Analysis (0)] |
4. | Arnold SV, Spertus JA, Tang F, Krumholz HM, Borden WB, Farmer SA, Ting HH, Chan PS. Statin use in outpatients with obstructive coronary artery disease. Circulation. 2011;124:2405-2410. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 50] [Cited by in F6Publishing: 55] [Article Influence: 4.2] [Reference Citation Analysis (0)] |
5. | Gopal DM, Santhanakrishnan R, Wang YC, Ayalon N, Donohue C, Rahban Y, Perez AJ, Downing J, Liang CS, Gokce N, Colucci WS, Ho JE. Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome. J Am Heart Assoc. 2015;4:e001597. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 31] [Cited by in F6Publishing: 33] [Article Influence: 3.7] [Reference Citation Analysis (0)] |
6. | Schoen MW, Salas J, Scherrer JF, Buckhold FR. Cholesterol treatment and changes in guidelines in an academic medical practice. Am J Med. 2015;128:403-409. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 13] [Cited by in F6Publishing: 15] [Article Influence: 1.7] [Reference Citation Analysis (0)] |
7. | Pokharel Y, Tang F, Jones PG, Nambi V, Bittner VA, Hira RS, Nasir K, Chan PS, Maddox TM, Oetgen WJ, Heidenreich PA, Borden WB, Spertus JA, Petersen LA, Ballantyne CM, Virani SS. Adoption of the 2013 American College of Cardiology/American Heart Association Cholesterol Management Guideline in Cardiology Practices Nationwide. JAMA Cardiol. 2017;2:361-369. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 61] [Cited by in F6Publishing: 84] [Article Influence: 16.8] [Reference Citation Analysis (0)] |
8. | Pencina MJ, Navar-Boggan AM, D'Agostino RB Sr, Williams K, Neely B, Sniderman AD, Peterson ED. Application of new cholesterol guidelines to a population-based sample. N Engl J Med. 2014;370:1422-1431. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 467] [Cited by in F6Publishing: 462] [Article Influence: 46.2] [Reference Citation Analysis (0)] |
9. | National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-3421. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 10261] [Cited by in F6Publishing: 9887] [Article Influence: 449.4] [Reference Citation Analysis (0)] |
10. | Schoen MW, Tabak RG, Salas J, Scherrer JF, Buckhold FR. Comparison of Adherence to Guideline-Based Cholesterol Treatment Goals in Men Versus Women. Am J Cardiol. 2016;117:48-53. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 13] [Cited by in F6Publishing: 16] [Article Influence: 2.0] [Reference Citation Analysis (0)] |
11. | Gotto AM, Grundy SM. Lowering LDL cholesterol: questions from recent meta-analyses and subset analyses of clinical trial DataIssues from the Interdisciplinary Council on Reducing the Risk for Coronary Heart Disease, ninth Council meeting. Circulation. 1999;99:E1-E7. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 58] [Cited by in F6Publishing: 65] [Article Influence: 2.6] [Reference Citation Analysis (0)] |
12. | Clough JD, Martin SS, Navar AM, Lin L, Hardy NC, Rogers U, Curtis LH. Association of Primary Care Providers' Beliefs of Statins for Primary Prevention and Statin Prescription. J Am Heart Assoc. 2019;8:e010241. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 19] [Cited by in F6Publishing: 21] [Article Influence: 4.2] [Reference Citation Analysis (0)] |
13. | Hinds A, Lopez D, Rascati K, Jokerst J, Srinivasa M. Adherence to the 2013 Blood Cholesterol Guidelines in Patients With Diabetes at a PCMH: Comparison of Physician Only and Combination Physician/Pharmacist Visits. Diabetes Educ. 2016;42:228-233. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 5] [Cited by in F6Publishing: 5] [Article Influence: 0.6] [Reference Citation Analysis (0)] |
14. | Institute of Medicine (US) Committee on Quality of Health Care in America. Crossing the Quality Chasm: A New Health System for the 21st Century. Washington, US: National Academies Press, 2001. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 236] [Cited by in F6Publishing: 207] [Article Influence: 9.0] [Reference Citation Analysis (0)] |
15. | Patel N, Bhargava A, Kalra R, Parcha V, Arora G, Muntner P, Arora P. Trends in Lipid, Lipoproteins, and Statin Use Among U.S. Adults: Impact of 2013 Cholesterol Guidelines. J Am Coll Cardiol. 2019;74:2525-2528. [PubMed] [DOI] [Cited in This Article: ] [Cited by in Crossref: 16] [Cited by in F6Publishing: 29] [Article Influence: 7.3] [Reference Citation Analysis (0)] |