Utility and correlation of known anticoagulation parameters in the management of pediatric ventricular assist devices

Figure 1 Scatterplots demonstrating correlation between standard measures of anticoagulation for patients on left ventricular assist device support. The estimated linear regression line (line of best fit) is shown along with 95%CI for individual value predictions for (A) anti-Xa and TEG-R levels, (B) aPTT and TEG-R levels, and (C) aPTT and anti-Xa levels. The R² values are shown alongside each panel (all P < 0.001). aPTT: Activated thromboplastin time; TEG: Thromboelastogram.

Figure 2 Correlation between platelet count and maximum amplitude after treatment with heparinase. The estimated linear regression line (line of best fit along with 95%CI) is shown for platelet counts and TEG-MA (heparinase). Correlation coefficient of 0.541 (P < 0.001). TEG: Thromboelastogram.

Figure 3 Scatterplots demonstrating correlation between unfractionated heparin dose and (A) activated thromboplastin time (B) Anti-Xa levels and (C) thromboelastogram-R value. The estimated linear regression line (line of best fit) is shown along with 95%CI for individual value predictions. aPTT: Activated thromboplastin time; TEG: Thromboelastogram.

Figure 4 Dot-density plots of thromboelastogram (heparinase) parameters R (panel A), K (panel B), angle (panel C) and maximum amplitude (panel D) showing distribution of individual values. Abnormal values are represented by solid grey circles. TEG: Thromboelastogram.