Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes

Figure 1 Different ultrastructural appearances of mitochondria in the arterial intima. A, B: “Intact” appearances of mitochondria with well-defined cristae and well-preserved surrounding membranes; C-F: Destructive alterations of cristae and the formation of vacuole-like structures (shown by arrows) in zones of edematous matrix of mitochondria. Electron microscopy, scale = 200 nm.

Figure 2 Alterations of mitochondria in intimal cells in atherosclerotic lesions. A: Myelin-like structure within a swollen mitochondrion (shown by arrow); B-D: Destruction of cristae and surrounding membranes of mitochondria. Electron microscopy, scale = 200 nm.