Glucose lowering does not necessarily reduce cardiovascular risk in type 2 diabetes

Figure 1 Newer oral antidiabetic drugs, glucose levels, and cardiovascular risk. A: Dipeptidyl peptidase-4 (DPP-4) inhibitors, sodium-glucose cotransporter 2 inhibitors (SGLT-2i), and glucagon-like peptide-1 receptor agonists (GLP1-RA) are effective glucose lowering agents in patients with type 2 DM; B SGLT-2i and GLP1-RA have shown significant decreases in adverse cardiovascular events, whereas the effect of DPP-4 inhibitors on cardiovascular outcomes in diabetic patients has been neutral. DPP-4i: DPP-4 inhibitors; SGLT-2i: Sodium-glucose cotransporter 2 inhibitors; GLP1-RA: glucagon-like peptide-1 receptor agonists.