Angiotensin receptor blocker neprilysin inhibitors

doi:10.4330/wjc.v13.i8.325

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Aug 26, 2021 (publication date) through Jul 3, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Aug 26, 2021; 13(8): 325-339
Published online Aug 26, 2021. doi: 10.4330/wjc.v13.i8.325

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Figure 1 Three neurohumoral factors related to the pathology of chronic heart failure, and the targets of conventional remedies. ACEI: Angiotensin-converting enzyme inhibitors; ARB: Angiotensin receptor blockers; BB: β-blocker; BP: Blood pressure; HF: Heart failure; HR: Heart rate; MRA: Mineralocorticoid receptor antagonist; RAAS: Renin-angiotensin-aldosterone-system.

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Figure 2 Mechanism of sacubitril/valsartan on heart failure progression. AT1: Angiotensin II type 1; HF: Heart failure; NP: Natriuretic peptide; RAAS: Renin-angiotensin-aldosterone-system; SAC/VAL: Sacubitril/valsartan.

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Figure 3 The therapeutic options and treatment lines of patients with symptoms of heart failure with reduced ejection fraction. ACEI: Angiotensin-converting enzyme inhibitor; AF: Atrial fibrillation; ARB: Angiotensin receptor blocker; ARNI: Angiotensin receptor neprilysin inhibitor; BB: β-blocker; bpm: Beats per minute; CRT: Cardiac resynchronization therapy; HR: Heart rate; ICD: Implantable cardioverter defibrillator; LVEF: Left ventricular ejection fraction; MRA: Mineralocorticoid receptor antagonist; NYHA: New York Heart Association; SR: Sinus rhythm.

Citation: Usuda D, Higashikawa T, Hotchi Y, Usami K, Shimozawa S, Tokunaga S, Osugi I, Katou R, Ito S, Yoshizawa T, Asako S, Mishima K, Kondo A, Mizuno K, Takami H, Komatsu T, Oba J, Nomura T, Sugita M. Angiotensin receptor blocker neprilysin inhibitors. World J Cardiol 2021; 13(8): 325-339
URL: https://www.wjgnet.com/1949-8462/full/v13/i8/325.htm
DOI: https://dx.doi.org/10.4330/wjc.v13.i8.325