Drug-induced gingival overgrowth in cardiovascular patients

Figure 1 A complete response of a severe drug-induced gingival overgrowth case following seven weeks after amlodipine removal and six consecutive tooth scaling and cleaning treatments. A: Amlodipine induced gingival overgrowth successfully treated by vigorous weekly plaque control; B: Calculus removal during seven weeks following the drug withdrawal and substitution by angiotensin-converting enzyme inhibitor (courtesy of Prof. Vlaho Brailo).

Figure 2 An improvement in a heart transplant patient, whose medication included both cyclosporin and amlodipine, four weeks following professional teeth cleaning and switching to tacrolimus and alternative antihypertensive drug. A and B: Gingival overgrowth in a heart transplant patient receiving both cyclosporin and amlodipine; C and D: An improvement is observed following conservative periodontal treatment and four weeks of switching to tacrolimus and angiotensin-converting enzyme inhibitor.