Elevated interleukin-6 levels are associated with impaired outcome in cardiac transthyretin amyloidosis

Figure 1 Univariate analysis for clinical/laboratory/risk score parameters and interleukin-6. Parametric survival regression, loglogistic distribution, wild-type P values. CRP: C-reactive protein; IL6: Interleukin-6; NTProBNP: N-terminal pro-brain natriuretic peptide; GFR: Glomerular filtration rate.

Figure 2 Interleukin-6 values are depicted according to study group or Gillmore class. A: Study group; B: Gillmore class. Ctrl: Control group; asym ATTRv: Asymptomatic ATTRv; ATTRv: Symptomatic ATTRv amyloidosis; WT: Wild-type ATTR amyloidosis. Linear model P values for two-group comparisons and trend-test (Jonckheere-Terpstra). Median and median absolute deviation (mad) of non-log and non-z transformed data (pg/mL). Red dashed line: Median interleukin-6 value per group.

Figure 3 Kaplan-Meier curves for combined, decompensation and death or heart transplantation endpoints for dichotomized interleukin-6. Dashed: Parametric survival regression (log logistic distribution), wild-type P values.

Figure 4 Kaplan-Meier curves for combined, decompensation and death or heart transplantation endpoints for dichotomized interleukin-6 in N-terminal pro-brain natriuretic peptide and TroponinT stratified patients. Dashed: Parametric survival regression (loglogistic distribution), likelihood ratio P values. cTNT: cardiac TroponinT; IL6: Interleukin-6; NTProBNP: N-terminal pro-brain natriuretic peptide.