Who benefits from percutaneous closure of patent foramen ovale vs medical therapy for stroke prevention? In-depth and updated meta-analysis of randomized trials

Figure 1 PRISMA flow diagram of the study search.

Figure 2 Forest plot for stroke, transient ischemic attack and composite of ischemic stroke, transient ischemic attack and systemic embolism. PFO: Patent foramen ovale.

Figure 3 Forest Plot for mortality and major bleeding. PFO: Patent foramen ovale.

Figure 4 Forest plot for atrial fibrillation and procedural complications. PFO: Patent foramen ovale.

Figure 5 Subgroup analysis of stroke recurrence. PFOC: Patent foramen ovale closure.