Copyright
©The Author(s) 2017.
World J Biol Chem. Feb 26, 2017; 8(1): 4-12
Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.4
Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.4
Nanomaterial | Toxin/Venom | Application |
Polyethylenimine-coated hexagonal-phase NaYF(4):Yb,Er/Ce NPs | CTX from Leiurus quinquestriatus scorpion’s venom | Glioma visualization by laser scanning upconversion fluorescence microscopy |
Highly stable iron oxide NPs conjugated to CTX and Cy5.5 fluorescent dye | CTX | Near-infrared fluorescence imaging |
Amine-functionalized polysilane and supermagnetic iron oxide NPs | CTX | Antitumor drug retarding tumor invasiveness and deactivating membrane-bound MMP2 |
Supermagnetic iron oxide conjugated with methotrexate and CTX | CTX | Antitumor drug with high cytotoxicity against glioma cells in vitro |
Streptavidin-conjugated QDs | Biotinylated alpha-bungarotoxin from Bungarus multicinctus krait’s venom | Visualization of nicotinic acetylcholine receptor in the myocytes |
Gold NPs | Snake venom toxin NKCT1 | Potential anticancer agent |
Polyethylene glycol-grafted distearoylphosphatidylethanolamine NPs conjugated with ImI and loaded with paclitaxel | Alpha-conotoxin ImI from the cone snail Conus imperialis | Targeted antitumor drug |
Perfluorocarbon NPs | The cytolytic peptide melittin, derived from bee venom | Antitumor drug with reduced acute toxicity |
Gold NPs with radioisotope label | Bombesin from the frog Bombina bombina | Increase in uptake of the drug by tumor cells |
Biodegradable poly(D,L-Lactide-co-glycolide) NPs | Bee venom | Prolonged analgesic effect of the venom |
Silica NPs | Walterinnesia aegyptia cobra’s venom | Significantly increased antitumor effects of the venom |
Poly(D,L-Lactide)-based NPs | Toxic fractions obtained from Androctonus australis hector and Buthusoccitanus tunetanus scorpions’ venoms | Enhanced immune response to weakly immunogenic toxins |
Chitosan NPs | Cobra Naja naja oxiana venom | Alternative to the currently used adjuvants |
- Citation: Utkin YN. Modern trends in animal venom research - omics and nanomaterials. World J Biol Chem 2017; 8(1): 4-12
- URL: https://www.wjgnet.com/1949-8454/full/v8/i1/4.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v8.i1.4