Basic Study
Copyright ©The Author(s) 2015.
World J Biol Chem. Nov 26, 2015; 6(4): 409-418
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.409
Table 1 List of kinase inhibitors used in a screening for compounds effective on epidermal growth factor receptor T790M/L858R
TargetCompound name
AKABT-702
AKT (PKB)Akt Inhibitor IV, Akt Inhibitor VIII, Akt Inhibitor XI
AMPKcompound C
ATMATM/ATR kinase inhibitor, ATM kinase inhibitor
Aurora kinaseAurora kinase/CDK inhibitor, aurora kinase inhibitor II, Aurora kinase inhibitor III
Bcr-ablAG957
BTKLFM-A13, terreic acid
CAMKIIKN-93, KN-62, Lavendustin C
CDKKenpaullone, purvalanol A, Olomoucine, Alsterpaullone, Cdk1/2 inhibitor III, Cdk2/9 inhibitor, NU6102, Cdk4 inhibitor, NSC625987
ChkSB218078, Isogranulatimide, Chk2 inhibitor, Chk2 inhibitor II
CKEllagic acid (dihydrate), TBB, DMAT, D4476
ClkTG003
DGKDiacylglycerol kinase inhibitor II
DNA-PKIC60211
eEF2 kinaseTX-1918
EGFRBPIQ-II, AG1478, AG490
FGFRSU4984, SU5402
Flt-3Flt-3 Inhibitor
FmscFMS Receptor Inhibitor
FynSU6656
GSKGSK-3 inhibitor IX, 1-Azakenpaullone, Indirubin-3’-monoxime
HER2AG825
IGF-IRAG1024, AGL 2263
IKKBMS-345541, IKK-2 inhibitor VI
IRAKIRAK-1/4 inhibitor
JAKJAK Inhibitor I, JAK3 Inhibitor VI
JNKSP600125, JNK inhibitor VIII
LckDamnacanthal, PP2
MAPKERK inhibitor II
MEKPD98059, U-0126, MEK inhibitor I
MetSU11274
MLCKML-7
p38 MAPKSB202190, SB239063
PDGFRAG1296, SU11652, PDGF receptor inhibitor V, PDGF receptor inhibitor IV
PI3KLY-294002, Wortmannin
PKAH-89, 4-cyano-3-methylisoquinoline
PKCBisindolymaleimide I, Go7874
PKGRp-8-CPT-cGMPS, KT5823
PKRPKR inhibitor
RafRAF1 kinase inhibitor I, ZM 336372
ROCKH-1152, Y-27632
Hsp90radicicol
SrcPP1 analog
SykSyk inhibitor
TGF-bRISB431542, TGF-beta RI kinase inhibitor II
Tpl2Tpl2 kinase inhibitor
TrKATrkA inhibitor
VEGFRVEGFR receptor inhibitor II, VEGF recptor 2 inhibitor I, SU1498