MicroRNA regulation network in colorectal cancer metastasis

Table 1 Summary of microRNAs involved in the tumorigenesis and metastasis of colorectal cancer

	microRNA	Description	Ref.
microRNAs differentially expressed in colorectal cancers	miR-21	Associated to more advanced TNM stages and poorer survival	[11]
	miR-135b	Associated to disease-free and cancer-specific survival	[12]
	miR-150*, miR-125b-2*, miR-1179 and miR-139-3p	Up-regulated in colorectal cancer with metastasis.	[13]
microRNAs as diagnostic markers	Serum miR-29a	Up-regulated in patients with metastasis	[55]
	Circulating miR-221	Associated to poor survival	[53]
	Plasma miR-31	Up-regulated in stage III and IV	[51]
microRNAs involved in epithelial-mesenchymal transition	miR-21	Pdcd4,TGFβ receptor 2	[23,24]
	miR-574-5p,miR-17	Qki6/7,P130	[25,26]
	miR-200	ZEB1/2	[27,28]
	miR-9	E-cadherin	[29,30]
	miR-499-5p	Pdcd4	[31]
	miR-212	MnSOD	[32]
microRNAs involved in Angiogenesis	miR-17-92	TSP-1	[44]
	miR-194	TSP-1,THBS1	[40]
	miR-107	HIF-1,VEGF,DAPK,KLF4	[41]
	miR-145	p70S6K1	[42]

MnSOD: Manganese superoxide dismutase; TSP-1: Thrombospondin-1; THBS1: Thrombospondin; HIF: Hypoxia inducible factor; VEGF: Vascular endothelial growth factors.