Potent trophic activity of spermidine supramolecular complexes in in vitro models

Table 1 Spermidine-supramolecular complexes tested in the fibroblasts proliferation model

Spermidine concentration	Spermidine-HA	Spermidine-Alg	Spermidine-Gz
0 nmol/L	HA 0.1%	Alg 0.1%	Gz 0.1%
1 nmol/L	SMC 10-6:1	SMC 10-6:3	SMC 10-6:9
10 nmol/L	SMC 10-5:1	SMC 10-5:3	SMC 10-5:9
100 nmol/L	SMC 10-4:1	SMC 10-4:3	SMC 10-4:9
1 μmol/L	SMC 10-3:1	SMC 10-3:3	SMC 10-3:9
10 μmol/L	SMC 10-2:1	SMC 10-2:3	SMC 10-2:9
100 μmol/L	SMC 10-1:1	SMC 10-1:3	SMC 10-1:9
1 mmol/L	SMC 1:1	SMC 1:3	SMC 1:9

Each spermidine-supramolecular complex is represented as spermidine-to-polymer ratio (meq/meq), as calculated from the cationic equivalents from spermidine and the anionic equivalents from the polymer. HA: Hyaluronate; OHA: Oligomeric hyaluronate; Alg: Sodium alginate; Gz: Gantrez; SMC: Spermidine-supramolecular complexes.