Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation

Table 1 Complications after allogeneic hematopoietic stem cell transplantation

Infection, n (%)	Yes	38 (61)
	No	24 (39)
Onset of first symptoms of infection (d), median (range)		9 (0-27)
Mucositis, n (%)	Yes	26 (42)
	No	36 (58)
Onset of first symptoms of mucositis (d), median (range)		1 (0-20)
aGvHD, n (%)	0	32 (52)
	I	26 (42)
	II	3 (5)
	III	1 (2)
	IV	0 (0)
aGvHD, n (%)	Skin	28 (45)
	Intestines	3 (5)
	Liver	0 (0)
Time of aGvHD manifestation (d), median (range)		17 (8-29)

aGvHD: Acute graft-versus-host disease.

Table 2 Median and maximum values of serum levels of interferon-gamma (pg/mL) in patients with and without acute graft-versus-host disease in the post-transplantation period (between days +2 and +30)

		Median IFN-gamma after allo-HSCT	Maximum IFN-gamma after allo-HSCT
aGvHD 0	Me	0	12.950
	Q1	0	0.185
	Q3	2.268	32.035
aGvHD I-III	Me	0	6.535
	Q1	0	0
	Q3	1.650	20.870
Mann-Whitney U test (P)		0.619	0.473

Me: Median; Q1: Quartile 1; Q3: Quartile 3; aGvHD: Acute graft-versus-host disease; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; IFN: Interferon.

Table 3 Median and maximum values of serum levels of interferon-gamma (pg/mL) in patients with and without infection in the post-transplantation period (between days +2 and +30)

		Median IFN-gamma after allo-HSCT	Maximum IFN-gamma after allo-HSCT
Without infection	Me	0	2.260
	Q1	0	0
	Q3	0	10.675
Infection	Me	0.058	19.295
	Q1	0	1.210
	Q3	2.375	37.620
Mann-Whitney U test (P)		0.043	0.002

Me: Median; Q1: Quartile 1; Q3: Quartile 3; allo-HSCT: Allogeneic hematopoietic stem cell transplantation; IFN: Interferon.

Table 4 Serum levels of interferon-gamma (pg/mL) in patients divided into groups based on the occurrence of acute graft-versus-host disease and infection

IFN-gamma level (pg/mL)
Median (Q1-Q3)	Pre-C	Post-C (day -1)	+2	+4	+6	+10	+20	+30
Group I	0 (0-1.50)	0 (0-0)	0 (0-0.50)	0 (0-0.58)	0 (0-0)	0 (0-0.63)	0 (0-3.97)	0 (0-3.00)
Group II	0 (0-0)	0 (0-1.63)	0 (0-1.52)	0 (0-1.25)	0 (0-1.10)	0 (0-1.52)	8.25 (0.28-30.46)	17.58 (3.00-46.12)
Group III	0 (0-0.84)	0 (0-0)	0 (0-0)	0 (0-0)	0 (0-0)	0 (0-0)	0 (0-3.83)	1.05 (0-6.78)
Group IV	0 (0-0)	0 (0-0)	0 (0-0.52)	0 (0-3.45)	0 (0-12.7)	0 (0-4.32)	0.22 (0-2.51)	0 (0-4.30)
Kruskal-Wallis test (P)	0.305	0.077	0.714	0.431	0.123	0.517	0.014	0.008

Pre-C: Before conditioning treatment; Post-C: After conditioning treatment; Q1: Quartile 1; Q3: Quartile 3; IFN: Interferon.