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©The Author(s) 2022.
World J Biol Chem. Sep 27, 2022; 13(4): 72-82
Published online Sep 27, 2022. doi: 10.4331/wjbc.v13.i4.72
Published online Sep 27, 2022. doi: 10.4331/wjbc.v13.i4.72
Table 1 Complications after allogeneic hematopoietic stem cell transplantation
Infection, n (%) | Yes | 38 (61) |
No | 24 (39) | |
Onset of first symptoms of infection (d), median (range) | 9 (0-27) | |
Mucositis, n (%) | Yes | 26 (42) |
No | 36 (58) | |
Onset of first symptoms of mucositis (d), median (range) | 1 (0-20) | |
aGvHD, n (%) | 0 | 32 (52) |
I | 26 (42) | |
II | 3 (5) | |
III | 1 (2) | |
IV | 0 (0) | |
aGvHD, n (%) | Skin | 28 (45) |
Intestines | 3 (5) | |
Liver | 0 (0) | |
Time of aGvHD manifestation (d), median (range) | 17 (8-29) |
Table 2 Median and maximum values of serum levels of interferon-gamma (pg/mL) in patients with and without acute graft-versus-host disease in the post-transplantation period (between days +2 and +30)
Median IFN-gamma after allo-HSCT | Maximum IFN-gamma after allo-HSCT | ||
aGvHD 0 | Me | 0 | 12.950 |
Q1 | 0 | 0.185 | |
Q3 | 2.268 | 32.035 | |
aGvHD I-III | Me | 0 | 6.535 |
Q1 | 0 | 0 | |
Q3 | 1.650 | 20.870 | |
Mann-Whitney U test (P) | 0.619 | 0.473 |
Table 3 Median and maximum values of serum levels of interferon-gamma (pg/mL) in patients with and without infection in the post-transplantation period (between days +2 and +30)
Median IFN-gamma after allo-HSCT | Maximum IFN-gamma after allo-HSCT | ||
Without infection | Me | 0 | 2.260 |
Q1 | 0 | 0 | |
Q3 | 0 | 10.675 | |
Infection | Me | 0.058 | 19.295 |
Q1 | 0 | 1.210 | |
Q3 | 2.375 | 37.620 | |
Mann-Whitney U test (P) | 0.043 | 0.002 |
Table 4 Serum levels of interferon-gamma (pg/mL) in patients divided into groups based on the occurrence of acute graft-versus-host disease and infection
IFN-gamma level (pg/mL) | ||||||||
Median (Q1-Q3) | Pre-C | Post-C (day -1) | +2 | +4 | +6 | +10 | +20 | +30 |
Group I | 0 (0-1.50) | 0 (0-0) | 0 (0-0.50) | 0 (0-0.58) | 0 (0-0) | 0 (0-0.63) | 0 (0-3.97) | 0 (0-3.00) |
Group II | 0 (0-0) | 0 (0-1.63) | 0 (0-1.52) | 0 (0-1.25) | 0 (0-1.10) | 0 (0-1.52) | 8.25 (0.28-30.46) | 17.58 (3.00-46.12) |
Group III | 0 (0-0.84) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-0) | 0 (0-3.83) | 1.05 (0-6.78) |
Group IV | 0 (0-0) | 0 (0-0) | 0 (0-0.52) | 0 (0-3.45) | 0 (0-12.7) | 0 (0-4.32) | 0.22 (0-2.51) | 0 (0-4.30) |
Kruskal-Wallis test (P) | 0.305 | 0.077 | 0.714 | 0.431 | 0.123 | 0.517 | 0.014 | 0.008 |
- Citation: Rybicka-Ramos M, Markiewicz M, Suszka-Świtek A, Wiaderkiewicz R, Mizia S, Dzierżak-Mietła M, Białas K. Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation. World J Biol Chem 2022; 13(4): 72-82
- URL: https://www.wjgnet.com/1949-8454/full/v13/i4/72.htm
- DOI: https://dx.doi.org/10.4331/wjbc.v13.i4.72