Role of platelet plasma membrane Ca2+-ATPase in health and disease

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Sep 26, 2010 (publication date) through Dec 25, 2024

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Sep 26, 2010; 1(9): 265-270
Published online Sep 26, 2010. doi: 10.4331/wjbc.v1.i9.265

Table 1 Modes of regulation of plasma membrane Ca²⁺-ATPase in human platelets

Type of regulation	Effect on PMCA	Ref.
Ca²⁺/calmodulin	Stimulation	[20]
Protein-kinase-A-dependent phosphorylation	Stimulation	[9,12]
Tyrosine phosphorylation	Inhibition	[9,13,16,21]
Calpain-mediated cleavage (124 kDa)	Stimulation	[22]
Calpain-mediated cleavage (100 kDa and smaller)	Inhibition	[22]
Transcriptional/translational	Up- or downregulation depending on isoform	[23,24]

PMCA: Plasma membrane Ca²⁺-ATPase.

Citation: Dean WL. Role of platelet plasma membrane Ca²⁺-ATPase in health and disease. World J Biol Chem 2010; 1(9): 265-270
URL: https://www.wjgnet.com/1949-8454/full/v1/i9/265.htm
DOI: https://dx.doi.org/10.4331/wjbc.v1.i9.265