Plasma membrane calcium pumps and their emerging roles in cancer

Table 1 Altered expression of plasma membrane calcium ATPase isoforms during tumorigenesis detected in cell lines and clinical samples derived from cancer affected tissues

Cancer subtype	PMCA isoform	Relative change in pump expression compared to non-tumorigenic control		Ref.
		mRNA	Protein
Skin: SV40 transformed fibroblasts	PMCA1	↓	↓	[35]
	PMCA4	↓	ND	[35]
Lung: SV40 transformed fibroblasts	PMCA1	↓	↓	[35]
	PMCA4	↓	ND	[35]
Breast cancer: cell lines	PMCA1	↑	ND	[38,39]
	PMCA2	↑	ND	[38,39]
	PMCA4	↓	ND	[39]
Oral cancer: squamous cell carcinoma, patient tissue samples and cell lines	PMCA1	↓	↓	[42]
Colon: adenocarcinoma and benign colon tumors	PMCA4	↓	ND	[45]

PMCA: Plasma membrane calcium ATPase; ND: Not determined.