Ikaros isoforms: The saga continues

Figure 2 A model for IK-H regulation of human gene expression. A: Exon structure of IK-1 and IK-H. The 20 amino acids encoded by Exon 3B distinguish IK-H from IK-1. Zinc fingers responsible for DNA binding are shown in yellow. Zinc fingers responsible for dimerization are shown in blue; B: A protein complex that contains IK-1 homodimers binds DNA tightly, leading to a compact chromatin structure and gene repression. Binding of Ikaros protein complexes that contain IK-H changes chromatin into a permissive structure leading to activation of gene expression.