Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1

Figure 1 Location of casein kinase 2 phosphorylation sites on Ikaros. The phosphorylated amino acids are indicated by numbers at the top. The location of zinc fingers is indicated by yellow (F1-F4) and red bands (F5-F6). Exons (Ex) are indicated at the bottom. Exon 1 (untranslated) is not shown.

Figure 2 A model for the role of casein kinase 2 and protein phosphatase 1 in regulating Ikaros activity in T-cell differentiation and tumor suppression. CK2: Casein kinase 2.