Shuffling the cards in signal transduction: Calcium, arachidonic acid and mechanosensitivity

doi:10.4331/wjbc.v2.i4.59

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Apr 26, 2011 (publication date) through Jan 8, 2025

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World Journal of Biological Chemistry

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1949-8454

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Biol Chem. Apr 26, 2011; 2(4): 59-66
Published online Apr 26, 2011. doi: 10.4331/wjbc.v2.i4.59

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Figure 1 Simplified scheme showing arachidonic acid metabolism. COX: Cyclooxygenase; LOX: Lipoxygenase; CYP: Cytochrome P450 epoxygenase; PGs: Prostaglandins; TXs: Thromboxanes; LTs: Leukotrienes; EETs: Epoxyeicosatrienoic acids; HPETEs: Hydroperoxyeicosatetraenoic acids; DAG: Diacylglycerol; DAGL: DAG lipase; PA: Phosphatidic acid; PLD: Phospholipase D; sPLA2: Secretory phospholipase A2; cPLA2: Cytosolic phospholipase A2; iPLA2: Ca²⁺-independent phospholipase A2; PLC: Phospholipase C; PA-PH: Phosphatidic acid phosphatase; lyso-PC: Lysophosphatidylcoline; PAF: Platelet activating factor; LPCAT: LPC acetyltransferase; AEA: Arachidonoylethanolamide (anandamide); FAAH: Fatty acid amidohydrolase.

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Figure 2 Scheme showing transient receptor potential channels modulated by arachidonic acid and its metabolites. AA: Arachidonic acid.

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Figure 3 Simplified scheme showing the interplay between mechanical stimuli, arachidonic acid metabolism and calcium signaling. AA: Arachidonic acid; REC: Membrane receptors; SACs: Stretch activated calcium channels; PLD: Phospholipase D; PLC: Phospholipase C; MAPK: Mitogen-activated protein kinase; Ca_c: Ca²⁺ concentration; PLA2: Phospholipase A₂.

Citation: Munaron L. Shuffling the cards in signal transduction: Calcium, arachidonic acid and mechanosensitivity. World J Biol Chem 2011; 2(4): 59-66
URL: https://www.wjgnet.com/1949-8454/full/v2/i4/59.htm
DOI: https://dx.doi.org/10.4331/wjbc.v2.i4.59