Role of platelet plasma membrane Ca2+-ATPase in health and disease

Figure 1 Model for association of plasma membrane Ca²⁺-ATPase with the cytoskeleton and translocation to the filopodia during platelet activation. Plasma membrane Ca²⁺-ATPase (PMCA) is associated with CLP-36, actinin and actin in the resting platelet in small complexes. Upon platelet activation (arrow), actin polymerizes into long fibers resulting in formation of filopodia and translocation of PMCA into the filopodia where it remains active in the plasma membrane. Taken from reference 33 with permission from Schattauer GmbH, Stuttgart.