Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Oct 18, 2018; 9(1): 1-15
Published online Oct 18, 2018. doi: 10.4331/wjbc.v9.i1.1
Mutual interaction between oxidative stress and endoplasmic reticulum stress in the pathogenesis of diseases specifically focusing on non-alcoholic fatty liver disease
Junichi Fujii, Takujiro Homma, Sho Kobayashi, Han Geuk Seo
Junichi Fujii, Takujiro Homma, Sho Kobayashi, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, Yamagata 990-9585, Japan
Han Geuk Seo, Sanghuh College of Life Sciences, Konkuk University, Seoul 143-701, South Korea
Author contributions: Fujii J and Seo HG have mainly performed literature review; Homma T and Kobayashi S have largely contributed to experimental data in quoted original papers; based on discussion among them, the idea and the data have been integrated into this review article.
Supported by a Joint Research Project between Japan Society for Promotion of Science and National Research Foundation of South Korea (in part).
Conflict-of-interest statement: We declare no conflict of interest between the authors or with any institution in relation to the contents of this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Junichi Fujii, PhD, Professor, Department of Biochemistry and Molecular Biology, Graduate School of Medical Science, Yamagata University, 2-2-2 Iidanishi, Yamagata City, Yamagata 990-9585, Japan. jfujii@med.id.yamagata-u.ac.jp
Telephone: +81-23-6285227 Fax: +81-23-6285230
Received: July 27, 2018
Peer-review started: July 30, 2018
First decision: August 24, 2018
Revised: September 19, 2018
Accepted: October 11, 2018
Article in press: October 12, 2018
Published online: October 18, 2018
Processing time: 82 Days and 2.6 Hours
Core Tip

Core tip: Accumulated experimental data indicate that oxidative stress causes endoplasmic reticulum stress, which together leads to pathogenic damage to cells. The lipid metabolism in the liver is a sensitive target of these types of stress, which appears to be associated with non-alcoholic fatty liver disease.