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World J Biol Chem. Jan 26, 2011; 2(1): 14-24
Published online Jan 26, 2011. doi: 10.4331/wjbc.v2.i1.14
Published online Jan 26, 2011. doi: 10.4331/wjbc.v2.i1.14
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain
Jennifer Vandooren, Nathalie Geurts, Erik Martens, Philippe E Van den Steen, Ghislain Opdenakker, Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, Leuven B-3000, Belgium
Steven De Jonghe, Piet Herdewijn, Medicinal Chemistry, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, Leuven B-3000, Belgium
Author contributions: Vandooren J performed the majority of the experiments and wrote the majority of the manuscript; Geurts N, Martens E and Van den Steen PE performed the experiments and assisted in writing the manuscript; De Jonghe S and Herdewijn P provided the ChemBridge, ChemDiv and InterBioScreen compound library and were involved in study design; Opdenakker G co-ordinated the study and was involved in study design and writing and editing the manuscript.
Supported by A postdoctoral fellowship (Van den Steen PE) and a research assistantship (Geurts N) of the Fund for Scientific Research, Belgium (FWO-Vlaanderen)
Correspondence to: Ghislain Opdenakker, MD, PhD, Professor, Laboratory of Immunobiology, Rega Institute for Medical Research, University of Leuven, Minderbroederstraat 10, Leuven B-3000, Belgium. ghislain.opdenakker@rega.kuleuven.be
Telephone: +32-16-337341 Fax: +32-16-337340
Received: September 17, 2010
Revised: November 18, 2010
Accepted: November 25, 2010
Published online: January 26, 2011
Revised: November 18, 2010
Accepted: November 25, 2010
Published online: January 26, 2011
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