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World J Biol Chem. May 26, 2010; 1(5): 188-195
Published online May 26, 2010. doi: 10.4331/wjbc.v1.i5.188
Published online May 26, 2010. doi: 10.4331/wjbc.v1.i5.188
Protective effects of anti-ricin A-chain antibodies delivered intracellularly against ricin-induced cytotoxicity
Feng Wu, Shaoan Fan, Kam-Meng Tchou-Wong, Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, United States
Frank Martiniuk, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, United States
Seth Pincus, Department of Research, Children’s Hospital, 200 Henry Clay Avenue, New Orleans, LA 70118, United States
Sybille Müller, Immpheron, Inc., 5235 Athens-Boonesboro Road, Lexington, KY 40509, United States
Heinz Kohler, Markey Cancer Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536-0096, United States
Author contributions: Wu F and Fan S performed the experiments, analyzed the data and wrote the manuscript; Martiniuk F generated cell-permeable antibodies and performed experiments; Pincus S generated Alexa-labeled ricin and RAC18 antibody; Müller S and Kohler H provided consultation on conjugation of MTS peptide to antibodies; Tchou-Wong KM designed and supervised the studies and critically revised and reviewed the manuscript.
Supported by NIEHS Center Grant ES00260 (Tchou-Wong KM) and NIAID R21 Grant AI059476 (Tchou-Wong KM) from the National Institutes of Health
Correspondence to: Dr. Kam-Meng Tchou-Wong, Department of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, United States. tchouk02@nyumc.org
Telephone: +1-845-7313504 Fax: +1-845-3515472
Received: May 10, 2010
Revised: May 15, 2010
Accepted: May 22, 2010
Published online: May 26, 2010
Revised: May 15, 2010
Accepted: May 22, 2010
Published online: May 26, 2010
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