2024 - Professor of Medicine, State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China 2020 - present Associate Professor of Medicine, College of Medicine and Health, University of Exeter Medical School, UK 2019-present Visiting Professor, Xiamen University Medical School, China My laboratory studies membrane ion channels, transporters, and signalling pathways that associated with human diseases, for examples, stroke that regulated by WNK-SPAK/OSR1-KCC2/NKCC1, hypertension that regulated by WNK-SPAK/OSR1-NCC, and concern with elucidating and targeting ion transporters, kinases, protein-protein interactions using genetic mouse models, small molecules, CRISPR/Cas9 gene-editing technologies, and electrophysiology to aid discovery and validation of new potential drug targets. I am internationally recognized for his expertise in cellular chloride homeostasis and cell volume regulation and drug discovery. I have published more than 100 articles in journals including Cell, Nature Medicine, Cell Metabolism, Neuron, Nature Communications, EMBO molecular medicine, Science Signalling, Human Molecular Genetics etc. and has achieved more than 3800 citations, H-index=32, i10-index=52. His current research has been supported by the NIH R01, The Royal Society UK, NSFC, Alzheimer's Research UK and Commonwealth Commission Funding etc. I am currently a member of the editorial boards of 40 scientific journals, including Medicinal Research Reviews (Board Member), Journal of Modern Biology and Drug Discovery (Editor in Chief), Frontiers in Pharmacology (Associate Editor), Frontiers in Microbiology (Associate Editor), and Frontiers in Physiology (Associate Editor), and completed editing >150 manuscripts, as well as a reviewer for more than 60 scientific journals including Cell Metabolism, Chem etc. and completed reviewing >200 manuscripts. The overall goal of my research is to understand the principles of how signal transduction is mediated by the posttranslational modification of proteins, to understand the molecular mechanisms of disease in order to improve human health, and our work links molecules, mechanism and medicine. My collaborative work with international research teams and institutions, including the University of Exeter and Yale, reflects my strong interpersonal skills. As Deputy Director and Principal Investigator, I have led research projects, secured funding, and mentored junior researchers. My leadership is evident in my editorial roles. I mentor students at the University of Exeter, demonstrated by my completion of the Postgraduate Certificate of Academic Practice and Fellowships. I manage complex research projects, oversee laboratories, and coordinate with team members as a senior lecturer and deputy director. In my personal time, I enjoy running, playing ball games, singing, and gardening. These activities provide a balanced mix of physical exercise, creativity, and relaxation, allowing me to maintain a healthy and active lifestyle.