Laparoscopic complete mesocolic excisions for colonic cancer in the last decade: Five-year survival in a single centre

Table 1 Characteristics of 341 tumour-nodal-metastasis stages 0-III patients with colonic cancer, operated on with laparascopic complete mesocolic excision resection in a community teaching hospital in Norway in 2007-2015

Variable category	Laparoscopic CME resection, n = 341 (%)
Age in years, mean, (range)	71.9 (28-94)
BMI in kg/m2, mean (range)	25.8 (15-42)
Surgical procedure
Right hemicolectomy	140 (41.1)
Extended right hemicolectomy	49 (14.4)
Left extended hemicolectomy	26 (7.6)
Sigmoid resection	126 (37.0)
TNM stage
Stage 0	8 (2.3)
Stage I	61 (17.9)
Stage II	170 (49.9)
Stage III	102 (29.9)
No. of lymph nodes, mean (range)	17.8 (0-69)
No. of positive lymph nodes, TNM st III, mean (range)	1.2 (0-19)
Length of stay, d, mean (range)	6.7 (2-57)

TNM: Tumour-nodal-metastasis; CME: Complete mesocolic excision; BMI: Body mass index.

Table 2 Operative morbidity and mortality in 341 patients with colonic cancer (tumour-nodal-metastasis stage 0-III) operated on with laparoscopic complete mesocolic excision in a community teaching hospital in Norway in 2007-2015 n (%)

Variables Category	Laparoscopic CME colectomy (n = 341)
Morbidity
No morbidity	267 (78.8)
Paralytic ileus	17 (5.0)
Wound infection	4 (1.2)
Wound dehiscence	8 (2.3)
Deep (IAA) infection	5 (1.5)
Anastomotic leakage	15 (4.4)
Cardiac/respiratory distress	11 (3.2)
Ileus reoperation	2 (0.6)
Other (bladder infection, iatrogenic perf small intestine)	6 (1.8)
Mortality	4 (1.2)

TNM: Tumour-nodal-metastasis; CME: Complete mesocolic excision; IAA: Intra-abdominal abscess.

Table 3 Five-year survival figures given as time to recurrence and cancer-specific survival according to tumour-nodal-metastases stages 0-III in 341 colon cancer patients that were operated on with laparoscopic complete mesocolic excision during 2007-2015 in one community teaching hospitals in Norway

Survival type TNM	5-yr survival (%)	P value1
TTR	83.1	< 0.001
Stage 0	100
Stage I	91.9
Stage II	87.3
Stage III	69.5
CSS	90.3	< 0.001
Stage 0	100
Stage 1	100
Stage 2	94.4
Stage 3	77

¹Adjusted for TNM stage with the log rank test. TNM: Tumour-nodal-metastases; CME: Complete mesocolic excision; TTR: Time to recurrence; CSS: Cancer-specific survival.

Table 4 Uni- and multi-variate analysis of 5-year time to recurrence for 341 patients operated for tumour-nodal-metastases stage 0-III colonic cancer in a Norwegian community teaching hospital

	Unadjusted HR (95%CI)	LR test P value	Adjusted HR (95%CI)	LR test P value
Age		0.665		0.673
< 70 yr	1 (reference)		1 (reference)
> 70 yr	0.89 (0.51, 1.54)		1.15 (0.60, 2.20)
BMI	1.01 (0.94, 1.08)	0.777	1.01 (0.94, 1.08)	0.855
Operative procedure		0.696		0.367
Right hemicolectomy	1 (reference)		1 (reference)
Extended right hemicol	0.70 (0.37, 1.30)		1.96 (0.76, 5.08)
Extended left hemicol	0.97 (0.43, 2.17)		1.63 (0.51, 5.23)
Anterior resection	0.87 (0.30, 2.52)		1.85 (0.88, 3.88)
Lymph nodes	1.02 (0.98, 1.05)	0.356	1.00 (0.97, 1.05)	0.652
Positive lymph nodes	1.16 (1.09, 1.23)	< 0.001	1.21 (1.13, 1.29)	< 0.001
Anastomotic leakage		0.045		0.019
No leak	1 (reference)		1 (reference)
Leak, reoperated	2.57 (1.02, 6.47)		3.13 (1.21, 8.10)

BMI: Body mass index; LR: Likelihood ratio.