How does epidemiological and clinicopathological features affect survival after gastrectomy for gastric cancer patients-single Egyptian center experience

Table 1 Co-morbidity and possible risk factors

Symptoms	n (%)
Abdominal pain	80 (100)
Dyspepsia	65 (81)
Heart burn	29 (36)
Dysphagia	17 (21)
Palpable mass	7 (9)
Co-morbidity
Helicobacter pylori	66 (83)
Smokers	56 (70)
Diabetes mellitus	16 (20)
Hypertension	16 (20)
Total	80 (100)

Table 2 Preoperative endoscopic evaluation

Item	n (%)
Site of tumor:
Antrum	51 (64)
Body	19 (24)
Fundus	10 (12)
Macroscopic feature:
Exophytic growth	46 (58)
Ulcerative form	34 (42)
Diffuse form	0
Total	80 (100)

Table 3 Complications after gastrectomy

	n (%)
Anastomotic leakage	3 (4)
Internal hemorrhage	1 (1)
Splenic bed collection	2 (3)
Pleural effusion	2 (3)
Wound infection	2 (3)
Total	10 (13)

Table 4 Pattern of recurrence

Item	n (%)
Local recurrence	9 (11)
Lymph nodes metastasis	2 (3)
Liver metastasis	2 (3)
Total	13 (16)

Table 5 Demographic and clinicopathological features predicting overall survival

Characteristics	Number of patients n (%)	Months after surgery (mean ± SD)	P value
Sex
Male	57 (71)	50.2 ± 3.1
Female	23 (29)	47.8 ± 4.6	P = 0.830
Age
Below 60	49 (61)	47.3 ± 3.5
Above 60	31 (39)	53.6 ± 3.6	P = 0.259
Site
Antrum	51 (64)	47 ± 3.5
Body	19 (24)	57.2 ± 3.5
Fundus	10 (12)	40.3 ± 6	P = 0.315
Type of surgery
Total gastrectomy	30	65 ± 7
Subtotal gastrectomy	50	60	P = 0.548
Tumor differentiation
Well	37 (46)	65.6 ± 0.3
Moderate	20 (25)	50.8 ± 5.3
Poor	23 (29)	20.8 ± 4	P = 0.001
T stage
T1	10 (13)	60 ± 3.2
T2	25 (31)	60 ± 2.4
T3	29 (36)	61 ± 3
T4	16 (20)	12 ± 2.3	P = 0.001
LN ratio
0	7 (9)	61
≤ 0.2	20 (25)	62 ± 2.5
0.2-0.4	26 (32)	62 ± 2.1
> 0.4	27 (34)	22 ± 4.5	P < 0.001
LN status
Negative	7 (9)	61 ± 3.5
Positive	73 (91)	31 ± 2.3	P = 0.03
Number of examined LN
> 15	65 (81)	54.48 ± 2.6
≤ 15	15 (19)	14.5 ± 1	P < 0.001
Surgical margin
Negative	73 (91)	53.8 + 2.4
Positive	7 (9)	9.5 + 1	P < 0.001
Recurrence
No	67 (84)	57.3 + 2.3
Yes	13 (16)	12.3 + 1.2	P < 0.001

Table 6 Multivariate analysis

Factors	Odds ratio	CI lower-upper	P value
Tumor differentiation	0.142	0.045-1.092	0.044
Radicality of resection	2.57	1.4-5.1	0.001
Number of resected lymph node > 15	2.04	1.3-3.75	0.001

Table 7 Published series on prognostic factors after resection for gastric carcinoma

Ref.	Period	No.	Gender	Age	Location	No. excised NL	LN ratio	T stage	Histologic type	N stage	Curative resection
Adachi et al[45]	1977-1987	479	NS	NS	P < 0.01	P < 0.01	NR	P < 0.01	P < 0.01	P < 0.01	NR
Bando et al[27]	1974-1995	650	NR	NR	NR	P < 0.001	P < 0.001	P < 0.001	NS	NR	NR
Yokota et al[46]	1985-1995	926	NS 0.347	NS 0.099	P < 0.0001	NR	NR	P < 0.0001	P < 0.0001	P < 0.0001	NR
Angelov et al[47]	2005-2013	101	NS 0.587	NS 0.67	NS 0.54	NR	NR	NR	NR 0.169	P = 0.003	P < 0.001
Basaran et al[48]	2006-2014	228	NS	P < 0.0001	P < 0.001	NR	NR	NS 0.137	P < 0.015	P < 0.002	P = 0.000
Present study	2009-2013	80	NS 0.83	NS 0.259	NS 0.315	P < 0.001	P < 0.001	P = 0.001	P = 0.001	NR	P < 0.001

NS: Non-significant; NR : Not reported; LN: Lymph node.